BENZIMIDAZOLE SCHIFF BASES MICROWAVE ASSISTED SYNTHESIS AND THE EFFECT ON LEUKEMIA CELLS WITH FLOW CYTOMETRY

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dc.contributor.authorCelik, Seyma Celikbilek
dc.contributor.authorVatansev, Husamettin
dc.contributor.authorKoc, Ziya Erdem
dc.date.accessioned2024-02-23T14:34:51Z
dc.date.available2024-02-23T14:34:51Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractThe present paper introduces a simple and efficient method for the synthesis of a 2-aryl-substituted benzimidazole by heterocyclization of 1,2-phenylenediamine and 5-aminoisophthalic acid in the presence of polyphosphoric acid as catalyst under solvent-less conditions, which produced good yield of corresponding benzimidazoles in a short reaction time. Two new bisbenzimidazoles and tetrakisbenzimidazole Schiff bases were synthesized by reaction between 3,5-di(1H-benzo[d]imidazol-2-yl)aniline (BIMA) and terephthalaldehyde or 4-formylbenzoic acid. The condensations proceed in short time to give products which, in certain instances, are not readily attainable by conventional condensation techniques. Due to its good performance, the microwave device used in household was preferred. The structures of the compounds were assigned by FT-IR, H-1 NMR, C-13 NMR and elemental analysis. The effects of benzimidazoles and Schiff bases on the cancerous cells have been known. Synthesized by bisbenzimidazole and bisbenzimidazole/tetrakisbenzimidazole-Schiff bases derivatives 3,5-di(1H-benzo[d]imidazol-2-yl)aniline (BIMA), N, N'-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(3,5-di(1H-benzo[d]imidazol-2-yl)aniline) (PM-BIMA), (E)-4-((3,5-di(1H-benzo[d]imidazol-2-yl)phenylimino)methyl)benzoic acid (BIM-PMBA) with flow cytometric analysis was performed, blastic cells containing 90%. We measured rates of cell death in cells blast on the matter.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University [16401145]en_US
dc.description.sponsorshipThis work is supported by The Research Foundation of Selcuk University (project number: 16401145).en_US
dc.identifier.doi10.33224/rrch.2019.64.7.08
dc.identifier.endpage623en_US
dc.identifier.issn0035-3930
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85072624800en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage615en_US
dc.identifier.urihttps://doi.org/10.33224/rrch.2019.64.7.08
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15751
dc.identifier.volume64en_US
dc.identifier.wosWOS:000486623600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofRevue Roumaine De Chimieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazoleen_US
dc.subjectSchiff Baseen_US
dc.subjectCytotoxicityen_US
dc.subjectFlow Cytometryen_US
dc.subjectBlastic Cellsen_US
dc.titleBENZIMIDAZOLE SCHIFF BASES MICROWAVE ASSISTED SYNTHESIS AND THE EFFECT ON LEUKEMIA CELLS WITH FLOW CYTOMETRYen_US
dc.typeArticleen_US

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