Ambulatory Blood Pressure and Subclinical Cardiovascular Disease in Children With Turner Syndrome

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dc.contributor.authorAkyurek, Nesibe
dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorEklioglu, Beray Selver
dc.contributor.authorAlp, Hayrullah
dc.date.accessioned2024-02-23T13:43:34Z
dc.date.available2024-02-23T13:43:34Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractPatients with Turner syndrome (TS) have an increased risk of cardiovascular morbidity. 29 TS and 25 healthy control subjects (CS) were included in the study. We investigated body mass index, waist circumference, fasting glucose and insulin, homeostatic model assessment (HOMA) index, serum lipids, oral glucose tolerance test, 24-h ambulatory blood pressure (BP) monitoring, and carotid intima-media thickness (CIMT) and compared them with CS. 28 % (N = 7) of TS had insulin resistance (IR), and 36 % (N = 9) had IGT. Mean systolic BP and diastolic BP (DBP) dip were 7.24 +/- A 3.97 % and 11.84 +/- A 6.2 %, respectively. CIMT was greater in TS than in CS (p = 0.00). CIMT was correlated positively with fasting insulin, HOMA index, and insulin-sensitivity check index (r = 0.563, p = 0.015; r = 0.603, p = 0.008; and r = 0.623, p = 0.006, respectively) and negatively with fasting glucose-to-insulin ratio and DBP dipping (r = -0.534, p = 0.022; r = -0.534, p = 0.00, respectively) in the two groups combined. These results provide additional evidence for the presence of subclinical cardiovascular disease and its relation to hypertension in TS. They also indicate a significant relation between DBP dipping and increased arterial stiffness. It is also important to note that our findings show significant relationships between insulin sensitivity and cardiovascular changes and underline the importance of insulin resistance for predicting cardiovascular disease.en_US
dc.identifier.doi10.1007/s00246-013-0740-2
dc.identifier.endpage62en_US
dc.identifier.issn0172-0643
dc.identifier.issn1432-1971
dc.identifier.issue1en_US
dc.identifier.pmid23794013en_US
dc.identifier.scopus2-s2.0-84893643585en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1007/s00246-013-0740-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10860
dc.identifier.volume35en_US
dc.identifier.wosWOS:000329374800009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmbulatory Blood Pressureen_US
dc.subjectSubclinical Cardiovascular Diseaseen_US
dc.subjectTurner Syndromeen_US
dc.titleAmbulatory Blood Pressure and Subclinical Cardiovascular Disease in Children With Turner Syndromeen_US
dc.typeArticleen_US

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