Conjunctival impression cytology and tear film parameters in patients with multiple sclerosis

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dc.contributor.authorBelviranli, Selman
dc.contributor.authorOltulu, Pembe
dc.contributor.authorUca, Ali Ulvi
dc.contributor.authorGundogan, Ali Osman
dc.contributor.authorMirza, Enver
dc.contributor.authorAltas, Mustafa
dc.contributor.authorTurk, Nazli
dc.date.accessioned2024-02-23T13:56:11Z
dc.date.available2024-02-23T13:56:11Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractPurpose To evaluate conjunctival impression cytology (CIC) findings and tear film parameters in patients with multiple sclerosis (MS) compared with controls. Methods Thirty-three patients with MS (MS group) and 33 age- and sex-matched healthy subjects (control group) were included in this cross-sectional comparative study. CIC grades, tear break-up time (TBUT), Schirmer 1 test results, and Ocular Surface Disease Index (OSDI) scores were compared between the two groups, and correlations between CIC grade, TBUT, Schirmer 1 test result, OSDI score, Expanded Disability Status Scale score, and disease duration were analyzed. Results Mean CIC grade was higher in the MS group than in the control group (1.48 +/- 0.71 and 0.39 +/- 0.56, respectively; p < 0.001). In the MS group, CIC of the 14 participants (42.4%) was grade 2-3. In the control group, CIC of the only one participant (3.3%) was grade 2, and none of them was grade 3. TBUT (8.12 +/- 3.16, 13.06 +/- 4.23 s in MS and control groups, respectively; p < 0.001) and Schirmer 1 test results (8.45 +/- 5.75, 17.36 +/- 10.89 mm in MS and control groups, respectively; p < 0.001) were lower, and OSDI score (36.36 +/- 19.19, 13.70 +/- 15.36 in MS and control groups, respectively; p < 0.001) was higher in the MS group compared to the control group. Conclusion In patients with MS, objective findings of dry eye, subjective symptoms related to dry eye, and CIC abnormalities, including high grades of conjunctival squamous metaplasia and goblet cell loss, are more common. Patients with MS should be monitored for ocular surface alterations and dry eye disease.en_US
dc.identifier.doi10.1007/s10792-021-02031-5
dc.identifier.endpage600en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue2en_US
dc.identifier.pmid34599424en_US
dc.identifier.scopus2-s2.0-85116140681en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage593en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-021-02031-5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11115
dc.identifier.volume42en_US
dc.identifier.wosWOS:000702578300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDry Eye Diseaseen_US
dc.subjectConjunctival Squamous Metaplasiaen_US
dc.subjectSchirmer Testen_US
dc.subjectTear Break-Up Timeen_US
dc.subjectOcular Surface Disease Indexen_US
dc.subjectExpanded Disability Status Scaleen_US
dc.titleConjunctival impression cytology and tear film parameters in patients with multiple sclerosisen_US
dc.typeArticleen_US

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