SERUM LEVELS OF OXIDATIVE STRESS PARAMETERS IN POSTMENOPAUSAL VERSUS FERTILE WOMEN OF KUTAHYA CITY, TURKEY

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dc.contributor.authorErdogdu, Behic Selman
dc.contributor.authorYontem, Mustafa
dc.contributor.authorKocak, Fatma Emel
dc.contributor.authorYazar, Hayrullah
dc.date.accessioned2024-02-23T14:40:49Z
dc.date.available2024-02-23T14:40:49Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: Decreased concentration of both oestrogen hormone and vitamin D in postmenopausal period may lead to oxidative stress, lipid peroxidation, dyslipidaemia, osteoporosis, and cardiovascular diseases. The objectives of this study were to determine and compare the serum levels of oxidative stress parameters; TOS, TAS, OSI, PON-1, ARYL in postmenopausal and fertile women of Kutahya city, Turkey. Materials & Methods: This cross-sectional study was conducted at Department of Biochemistry, Faculty of Medicine, Kutahya University of Health Sciences, Kutahya, Turkey from July, 2016 to December, 2016. Kutahya is a city in western Turkey, with population of 237,804 as per 2011 estimates. Two samples were drawn from this population with consecutive technique. Study group included 40 menopausal women, while control group included 40 healthy fertile women. After overnight fasting, venous blood samples were collected, centrifuged, aliquoted into a polystyrene tube, and aliquots were stored at -80 degrees C until measurement for total oxidant status (TOS), total antioxidant status (TAS), paraoxonase-1 (PON-1), and arylesterase (ARYL) measurements were made. Levels of TOS, TAS, OSI, PON-1, ARYL were five research variables on ratio scale. `Normal' data were described by mean, range and SD and skewed data by median, Q1, Q3 and IQR with 95% confidence intervals. For normal data, independent-samples t-test and for skewed data Mann-Whitney U test was used for hypotheses testing. Results: Serum total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly higher (p-value.015 &.003 respectively), and serum paraoxonase-1 (PON-1) and arylesterase (ARYL) levels were significantly lower in postmenopausal than fertile women (p-value <.0001 &.0005 respectively), with no statistical difference for serum total antioxidant status (TAS) levels between the two groups (p-value.186). Conclusion: Postmenopausal period is associated with oxidative stress and decreased antioxidant defence. HDL-c-dependent PON-1 and ARYL activities are also reducing due to a decrease of HDL-c with menopause. Elevated levels of TOS and OSI, decreased levels of PON-1 and ARYL may lead to various life-threatening diseases such as cardiovascular disorders or cancer.en_US
dc.identifier.doi10.46903/gjms/19.01.934
dc.identifier.endpage27en_US
dc.identifier.issn1819-7973
dc.identifier.issn1997-2067
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85139253377en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.46903/gjms/19.01.934
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16598
dc.identifier.volume19en_US
dc.identifier.wosWOS:000707198900004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGomal Medical Collen_US
dc.relation.ispartofGomal Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectMenopauseen_US
dc.subjectPostmenopauseen_US
dc.subjectPostmenopausal Perioden_US
dc.subjectOxidative Stressen_US
dc.subjectArylesteraseen_US
dc.subjectParaoxonase-1en_US
dc.subjectWomenen_US
dc.titleSERUM LEVELS OF OXIDATIVE STRESS PARAMETERS IN POSTMENOPAUSAL VERSUS FERTILE WOMEN OF KUTAHYA CITY, TURKEYen_US
dc.typeArticleen_US

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