The determination of histopathological and biochemical effects of the rabbit knee joint injected dexketoprofen trometamol

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dc.contributor.authorHacibeyoglu, Gulcin
dc.contributor.authorSaritas, Tuba Berra
dc.contributor.authorSaritas, Zulfikar Kadir
dc.contributor.authorKorkmaz, Musa
dc.contributor.authorSevimli, Alper
dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorOtelcioglu, Seref
dc.date.accessioned2024-02-23T14:24:10Z
dc.date.available2024-02-23T14:24:10Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractThis study was conducted to investigate possible histopathological effects and biochemical reflections of intra-articular dexketoprofen trometamol. A total of 24 New Zealand rabbits were included in the study. Blood sampling was carried out from all animals on the first day, then they were randomly allocated either to the control group (GroupC, n=9) or the dexketoprofen trometamol group (GroupD, n=15). GroupC underwent each two intra-articular injections of saline, 0.25mL into right and 0.50mL into left knee. Group D was injected 0.25mL (6.25mg) dexketoprofen trometamol into the right knee and 0.50mL (12.5mg) into the left. The groups were divided randomly into three. Tissue and blood samples were collected from Groups C1 and D1 on the first day, C2 and D2 on the second day and C3 and D3 on the 10th day of the study. Interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-) and C-reactive protein (CRP) levels were studied. The histopathological examination of C and D groups did not present any deterioration. IL-6 basal levels were significantly higher in Group D2 compared with C2 and C3 compared with D3. Basal TNF- levels were higher compared with day 1 in Group C1, and IL-6 and CRP levels were higher in Group D3. Also, none of the increases in these values are supported by histopathological evaluation results. Consequently, we suppose that dexketoprofen trometamol does not cause histopathological deterioration in articular cartilage of rabbits, and the increases in biochemical parameters exclusively are not clinically significant.en_US
dc.identifier.doi10.1111/fcp.12074
dc.identifier.endpage85en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue1en_US
dc.identifier.pmid24673725en_US
dc.identifier.scopus2-s2.0-84921027249en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1111/fcp.12074
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13846
dc.identifier.volume29en_US
dc.identifier.wosWOS:000347832900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectDexketoprofen Trometamolen_US
dc.subjectInterleukin-1en_US
dc.subjectInterleukin-6en_US
dc.subjectRabbiten_US
dc.subjectTumour Necrosis Factor-Alphaen_US
dc.titleThe determination of histopathological and biochemical effects of the rabbit knee joint injected dexketoprofen trometamolen_US
dc.typeArticleen_US

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