Role of the systemic immune-inflammation index in threatened abortion patients and predicting of abortion

Basit Öğe Kaydı
dc.contributor.authorSoysal, Cenk
dc.contributor.authorSari, Hatice
dc.contributor.authorIsikalan, Mehmet Murat
dc.contributor.authorOzkaya, Eren Berkay
dc.contributor.authorUlas, Ozlem
dc.contributor.authorTasci, Yasemin
dc.contributor.authorKeskin, Nadi
dc.date.accessioned2024-02-23T14:24:31Z
dc.date.available2024-02-23T14:24:31Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPurpose: Our study aimed to compare the systemic immune inflammation index (SII), one of the hematological inflammation parameters, between pregnant women diagnosed with threatened abortion (TA) and healthy pregnant women, and to evaluate the prediction of abortion in pregnant women with TA. Methods: This retrospective study compared 150 patients with TA group and 150 age- and gestational week-matched healthy pregnant women (control group). Complete blood count parameters were assessed. SII, white blood cells (WBC), neutrophil to lymphocyte ratio (NLR), red cell distribution width (RDW), plateletcrit (PCT), platelet distribution width and monocyte to lymphocyte ratio (MLR) values were calculated. The SII value was calculated as follows: platelet count x (neutrophil/lymphocyte). Results: SII, NLR, MLR, WBC, RDW, and PCT values were significantly higher in the TA group compared to the control group (923 +/- 683 vs. 579 +/- 364 [p < 0.001], 3.3 +/- 2.0 vs. 2.1 +/- 1.1 [p < 0.001], 0.3 +/- 0.1 vs. 0.2 +/- 0.2 [p < 0.001], 9.84 +/- 2.87 vs. 8.6 +/- 1.6 [p < 0.001], 13.9 +/- 1.9 vs. 14.4 +/- 2.3 [p = 0.032] and 0.3 +/- 0.1 vs. 0.2 +/- 0.0 [p < 0.001], respectively). Using receiver operating characteristics curve analysis to predict abortion in AI patients, the highest area under the curve was found for SII (0.727 for SII and 0.666 for NLR). Conclusion: SII, NLR, MLR, RDW, and platelet to lymphocyte ratio (PLR) levels were significantly increased in patients with TA. This study supports the idea that several inflammatory pathways may play an important role in the pathogenesis of this disorder. SII may be a much better marker than NLR and PLR for predicting the inflammatory status of the disease and abortion in an ongoing pregnancy.en_US
dc.description.sponsorshipDr. Anita L. Akkas (Middle East Technical University-ret, Ankara, Turkey)en_US
dc.description.sponsorshipThe authors would like to thank Dr. Anita L. Akkas (Middle East Technical University-ret, Ankara, Turkey) for contributing to the English editing.en_US
dc.identifier.doi10.1111/jog.15655
dc.identifier.endpage1728en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue7en_US
dc.identifier.pmid37088799en_US
dc.identifier.scopus2-s2.0-85153513173en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1723en_US
dc.identifier.urihttps://doi.org/10.1111/jog.15655
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13982
dc.identifier.volume49en_US
dc.identifier.wosWOS:000976607500001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectPlatelet/Lymphocyte Ratioen_US
dc.subjectRed Cell Distribution Widthen_US
dc.subjectSystemic Immune-Inflammation Indexen_US
dc.subjectThreatened Abortionen_US
dc.titleRole of the systemic immune-inflammation index in threatened abortion patients and predicting of abortionen_US
dc.typeArticleen_US

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