Anti-proliferative and apoptotic effects of green synthesized silver nanoparticles using Lavandula angustifolia on human glioblastoma cells

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dc.contributor.authorSimsek, Aysel
dc.contributor.authorPehlivanoglu, Suray
dc.contributor.authorAcar, Cigdem Aydin
dc.date.accessioned2024-02-23T14:00:01Z
dc.date.available2024-02-23T14:00:01Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIn this study, we aimed at the green synthesis of silver nanoparticles (AgNPs) using Lavandula angustifolia extract and the investigation of the anti-proliferative and apoptotic inducing effects of these nanoparticles in the U87MG glioblastoma cancer cell line. Green synthesized silver nanoparticles were characterized by various analytical techniques such as UV-Visible Spectrophotometer (UV-Vis), scanning electron microscopy (SEM) and Energy Dispersive X-ray (EDX). UV-Vis spectroscopy displayed a specific silver plasmon peak at 430 nm. U87MG cells were treated at increased concentrations with Lavandula angustifolia-AgNPs (La-AgNPs) (0-20 mu g/mL) for 72 h and the anti-proliferative effects of green synthesized silver nanoparticles on U87MG cells were evaluated by MTT assay. The La- AgNPs induced a statistically significant dose-dependent decrease in proliferation and increased cytotoxicity in U87MG cells. The IC50 value is 7.536 mu g/mL. Furthermore, the expression of apoptosis proteins caspase-3, caspase-8 and caspase-9 was analyzed using ELISA and caspase-3 and p53 using western blotting. The results suggest that La-AgNPs induce cell death in U87MG cells through the p53 mediated intrinsic apoptotic pathway. Together, the present findings suggest that La-AgNPs could be considered as a potential option for the treatment of glioblastoma.en_US
dc.description.sponsorshipBurdur Mehmet Akif Ersoy University Scientific Research Rrojects Unit [0617-YL-19]en_US
dc.description.sponsorshipThis research was supported by the Burdur Mehmet Akif Ersoy University Scientific Research Rrojects Unit [Project number: 0617-YL-19].en_US
dc.identifier.doi10.1007/s13205-021-02923-4
dc.identifier.issn2190-572X
dc.identifier.issn2190-5738
dc.identifier.issue8en_US
dc.identifier.pmid34367866en_US
dc.identifier.scopus2-s2.0-85110736025en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s13205-021-02923-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11424
dc.identifier.volume11en_US
dc.identifier.wosWOS:000691836900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartof3 Biotechen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSilver Nanoparticlesen_US
dc.subjectAgnpsen_US
dc.subjectGlioblastomaen_US
dc.subjectU87mgen_US
dc.titleAnti-proliferative and apoptotic effects of green synthesized silver nanoparticles using Lavandula angustifolia on human glioblastoma cellsen_US
dc.typeArticleen_US

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