Cystatin C as a potential biomarker to evaluate migraine

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dc.contributor.authorAkdag, Turan
dc.contributor.authorUca, Ali Ulvi
dc.date.accessioned2024-02-23T14:32:08Z
dc.date.available2024-02-23T14:32:08Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractBackground: Migraine is a multifactorial neurovascular syndrome and closely associated to inflammation. Cystatin C (Cys C) is a neuroendocrine polypeptide which also plays a role in inflammation. Objective: To investigate the levels of Cys C in migraine patients without aura. Methods: A total of 80 participants were included in the study; 40 patients and 40 healthy controls. Serum Cys C levels were investigated by using enzyme-linked immunosorbent assay (ELISA). Statistical analysis were performed using Statistical Package for the Social Sciences (SPSS) version 22.0 (SPSS Inc, IL, USA). Results: Serum Cys C levels were found as 73.88 ng/mL in the patient group and 24.92 ng/mL in the healthy control group, being significantly higher among patients (p=0.000). Serum Cys C levels were significacntly different across age subgroups among patients (p=0.049), but not among controls. However, visual analog scale (VAS) (p=0.707), disease duration time (p=0.725) and body mass index (p=0.136) were not significantly different between the two groups. Conclusion: Our findings demonstrate that high serum Cys C levels are independently associated to migraine without aura. To the best of our knowledge, this is the first study to determine the serum levels of Cys C in patients with migraine. Thus, serum Cys C may be a potential biomarker of migraine.en_US
dc.description.sponsorshipResearch Fund of the Necmettin Erbakan University [181235002]en_US
dc.description.sponsorshipResearch was supported by the Research Fund of the Necmettin Erbakan University. Project number: 181235002, Konya/Turkey. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.en_US
dc.identifier.doi10.1590/0004-282X20200005
dc.identifier.endpage341en_US
dc.identifier.issn0004-282X
dc.identifier.issn1678-4227
dc.identifier.issue6en_US
dc.identifier.pmid32609189en_US
dc.identifier.scopus2-s2.0-85087533744en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://doi.org/10.1590/0004-282X20200005
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15513
dc.identifier.volume78en_US
dc.identifier.wosWOS:000544249700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Arquivos Neuro- Psiquiatriaen_US
dc.relation.ispartofArquivos De Neuro-Psiquiatriaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMigraine Disordersen_US
dc.subjectCystatin Cen_US
dc.subjectHeadacheen_US
dc.titleCystatin C as a potential biomarker to evaluate migraineen_US
dc.typeArticleen_US

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