Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression?

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dc.contributor.authorSolak, Hatice
dc.contributor.authorGormus, Z. Isik Solak
dc.contributor.authorKoca, Raviye Ozen
dc.contributor.authorGunes, Canan Eroglu
dc.contributor.authorKutlu, Selim
dc.date.accessioned2024-02-23T13:59:24Z
dc.date.available2024-02-23T13:59:24Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractDepression is a chronic, recurrent and life-threatening disease affecting approximately 15% of the world population. Depression is responsible for neuropathologies like decreased neurogenesis and increased dendritic atrophy. Antidepressant treatments increase hippocampal neurogenesis and neurotrophic factor expression. Based on this information, it was aimed to investigate effect of sertraline on depression in rats with chronic mild stress (CMS) model and to determine how it affects cell proliferation and hypothalamic peptide levels in hypothalamus. 56 adult male Wistar albino; control, depression(D), depression + sertraline, sertraline were divided into groups. Various stressors were applied to D for 30 days. Open field test (OFT) and forced swimming test (FST) were conducted to check whether the animals were depressed. On the 16th day osmotic minipump was placed subcutaneously and sertraline (10 mg/kg/day) was administered for 15 days. Behavior tests were done. Hypothalamic peptide gene expression levels were analyzed by quantitative RT-PCR. Statistical evaluations were made using ANOVA. It caused a decrease in the percentage of movement in the D and control groups in the OFT, an increase in the immobility time in the D group in the FST, and an increase in the swimming behavior in the DS group. Animals did not show any anxiological behavior based on the elevated plus maze test results. CMS caused a decrease in GLUT2 and NPY gene expression in the hypothalamus of animals, an increase in POMC and FGFR2, and an increase in IGFIR and GLUT2 gene expression in the DS group. Sertraline has been shown to ameliorate the effects of CMS-induced depression. Sertraline is thought to have a positive regulatory effect on both the formation of neural precursor cells and the survival of newly formed neurons in the hypothalamus. Newly formed neurons in the hypothalamus express food intake-related NPY, POMC, GLUT2 neurons, and thus hypothalamic tanycytes may play a key role in the control of energy metabolism.en_US
dc.description.sponsorshipScientific Investigations Projects Coordinatorship of Necmettin Erbakan University [181418005]en_US
dc.description.sponsorshipThe study was supported by the Scientific Investigations Projects Coordinatorship of Necmettin Erbakan University (SIPC Project Number: 181418005).en_US
dc.identifier.doi10.1007/s11064-022-03529-9
dc.identifier.endpage1316en_US
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.issue5en_US
dc.identifier.pmid35080689en_US
dc.identifier.scopus2-s2.0-85123628948en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1299en_US
dc.identifier.urihttps://doi.org/10.1007/s11064-022-03529-9
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11170
dc.identifier.volume47en_US
dc.identifier.wosWOS:000747088900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypothalamusen_US
dc.subjectChronic Mild Stressen_US
dc.subjectDepressionen_US
dc.subjectSertralineen_US
dc.subjectFood Intake Peptidesen_US
dc.subjectRaten_US
dc.titleDoes Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression?en_US
dc.typeArticleen_US

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