Effects of oral colchicine administration as first-line adjunct therapy in myopericarditis

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dc.contributor.authorDuran, Mustafa
dc.contributor.authorAlsancak, Yakup
dc.contributor.authorZiyrek, Murat
dc.date.accessioned2024-02-23T13:43:28Z
dc.date.available2024-02-23T13:43:28Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground Although current guidelines recommend routine use of oral colchicine as a first-line adjunct therapy to aspirin/nonsteroidal anti-inflammatory drugs (NSAIDs) for acute and recurrent pericarditis, there are insufficient data to recommend routine use of colchicine for the initial management of myopericarditis. Methods The records of 194 patients who were admitted for myopericarditis were investigated retrospectively. Patients receiving oral colchicine (n = 33) as an adjunct to aspirin/NSAIDs comprised the study group and patients who received conventional therapy (n = 31) formed the control group. Plasma C-reactive protein (CRP) levels, cardiac biomarkers, and several electrocardiographic parameters of atrial activation were evaluated before the start of treatment and at the 6-month follow-up. Results Assessments before and after treatment with regard to cardiac biomarkers and plasma CRP levels showed improvements in both groups (p > 0.05). There were statistically significant improvements in P wave indices including P wave duration, PR interval length, P wave dispersion, P terminal force, and isoelectric interval in the colchicine therapy group compared with the control group (p < 0.01). Conclusion Routine use of colchicine for the initial management of myopericarditis as a first-line adjunct therapy to aspirin/NSAIDs in patients with myopericarditis has favorable effects on electrocardiographic indices of atrial activation parameters.en_US
dc.identifier.doi10.1007/s00059-021-05040-3
dc.identifier.endpage174en_US
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.issue2en_US
dc.identifier.pmid34114046en_US
dc.identifier.scopus2-s2.0-85107467695en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage166en_US
dc.identifier.urihttps://doi.org/10.1007/s00059-021-05040-3
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10824
dc.identifier.volume47en_US
dc.identifier.wosWOS:000660982300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUrban & Vogelen_US
dc.relation.ispartofHerzen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylsalicylic Aciden_US
dc.subjectCardiac Biomarkersen_US
dc.subjectMyopericarditisen_US
dc.subjectNonsteroidal Anti-Inflammatory Agenten_US
dc.subjectP Wave Indicesen_US
dc.titleEffects of oral colchicine administration as first-line adjunct therapy in myopericarditisen_US
dc.typeArticleen_US

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