The association between leptin receptor polymorphism and suicidal behaviour in depressed adolescents

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dc.contributor.authorAcikel, S. Burak
dc.contributor.authorEroglu, Canan
dc.contributor.authorDikmen, Asiye Ugras
dc.contributor.authorKurar, Ercan
dc.date.accessioned2024-02-23T14:20:33Z
dc.date.available2024-02-23T14:20:33Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjective: Suicide is the second leading cause of death in adolescence. Genetic studies implicate the genetic component of suicide independent from associated psychiatric disorder. Although genetics is an important factor that might be associated with suicide, limited progress is achieved to identify the candidate genes in adolescents. Methods: The study included 97 patients and 106 controls. Five leptin receptor single nucleotide polymorphism (SNP) region examined. Depressive scores were measured with Children Depression Inventory and suicidal behaviour was measured by Suicide Probability Scale. Logistic and linear regression analysis used for determining to predictors. Results: In linear regression analysis (R-2: 0.786) both previous suicide attempt (B:5.553, t:2.613 p: .035) and having a mutant allele in rs1171276 SNP region (B:4.346 t:2.220 p: .048) have been associated with suicidal behaviour. In logistic regression analysis, family history of depression (p < .0001, OR: 4.2 [1.7-9.6]) and number of stressful life events (p: .001, OR: 1.7 [1.3-2.1]) predicted depression significantly. Conclusion: Leptin receptor polymorphism could result in an increase in impulsive behaviour and suicide scores with leptin resistance. Our research is the first study to investigate the relationship between depression, suicidal behaviour and leptin receptor polymorphism in adolescent sample. Similar studies could be carried out on a community basis.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Commission [161518007]en_US
dc.description.sponsorshipThis study has been supported by Necmettin Erbakan University Scientific Research Projects Commission with project number (161518007).en_US
dc.identifier.doi10.1080/13651501.2019.1711422
dc.identifier.endpage126en_US
dc.identifier.issn1365-1501
dc.identifier.issn1471-1788
dc.identifier.issue2en_US
dc.identifier.pmid31916884en_US
dc.identifier.scopus2-s2.0-85078632196en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.1080/13651501.2019.1711422
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13208
dc.identifier.volume24en_US
dc.identifier.wosWOS:000506332000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Psychiatry In Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeptinen_US
dc.subjectDepressionen_US
dc.subjectGeneticsen_US
dc.subjectImpulsive Behaviouren_US
dc.subjectSuicideen_US
dc.titleThe association between leptin receptor polymorphism and suicidal behaviour in depressed adolescentsen_US
dc.typeArticleen_US

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