Atherogenic index of plasma: a useful marker for subclinical atherosclerosis in ankylosing spondylitis

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dc.contributor.authorCure, Erkan
dc.contributor.authorIcli, Abdullah
dc.contributor.authorUslu, Ali Ugur
dc.contributor.authorSakiz, Davut
dc.contributor.authorCure, Medine Cumhur
dc.contributor.authorBaykara, Rabia Aydogan
dc.contributor.authorYavuz, Fatma
dc.date.accessioned2024-02-23T13:55:56Z
dc.date.available2024-02-23T13:55:56Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractAnkylosing spondylitis (AS) is associated with an increased risk of atherosclerotic cardiovascular disease (ACD). The atherogenic index of plasma (AIP), which is the logarithmic transformation of the plasma triglyceride (TG) level to the high-density lipoprotein level (HDL) ratio, has been suggested to be a novel marker in the identification of atherosclerosis risk. Therefore, this study aims to determine if the AIP can act as an accurate marker for the detection of subclinical atherosclerosis. Fifty-two male patients with AS and 52 age-, gender-, and body mass index (BMI)-matched healthy control subjects were included in the study. For each patient, AIP and total cholesterol (TC)/HDL values were calculated and carotid artery intima-media thickness (cIMT) was measured. The mean (SD) cIMT and median (range) AIP values for AS patients were higher than that of the healthy control subjects (0.60 +/- 0.18 vs. 0.51 +/- 0.10, p = 0.003 and 0.23 [- 0.32 to 0.85] vs. 0.09 [- 0.53 to 0.49], p = 0.007, respectively). A positive correlation was found between the patients' cIMT and AIP values (r = 0.307, p = 0.002) and TC/HDL values (r = 0.241, p = 0.014). Regression analysis revealed an independent association between the subclinical atherosclerosis and AIP (beta [beta] = 0.309, p = 0.002). There were no independent correlations between subclinical atherosclerosis and TC (beta = 0.245, p = 0.065), TG (beta = 0.185, p = 0.515), HDL (beta = 0.198, p = 0.231), TC/HDL (beta = 0.032, p = 0.862), and low-density lipoprotein (LDL) (beta = 0.151, p = 0.246). A strong and independent correlation exists between AIP and cIMT values. Therefore, the AIP could serve as a better marker than the TC/HDL ratio for the detection of subclinical atherosclerosis in AS patients.en_US
dc.identifier.doi10.1007/s10067-018-4027-0
dc.identifier.endpage1280en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue5en_US
dc.identifier.pmid29435680en_US
dc.identifier.scopus2-s2.0-85041914632en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1273en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-018-4027-0
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11025
dc.identifier.volume37en_US
dc.identifier.wosWOS:000430711600016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectAtherogenic Index Of Plasmaen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectSubclinical Atherosclerosisen_US
dc.titleAtherogenic index of plasma: a useful marker for subclinical atherosclerosis in ankylosing spondylitisen_US
dc.typeArticleen_US

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