Level of kisspeptin-10 in patients with multiple sclerosis and the association between third ventricle diameter size and vitamin D level

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dc.contributor.authorAkdag, T.
dc.contributor.authorUca, A. U.
dc.contributor.authorAltas, M.
dc.contributor.authorOdabas, F. O.
dc.contributor.authorAktas, F.
dc.date.accessioned2024-02-23T14:32:06Z
dc.date.available2024-02-23T14:32:06Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: Multiple sclerosis (MS) is a chronic and progressive neurological disease affecting the central nervous system (CNS). Some studies report an association between MS pathogenesis and cytokines. Here, we aimed to determine and evaluate serum kisspeptin-10 level in MS patients and its related clinic parameters. Materials and Methods: A total of 92 participants, 46 patients with relapsing-remitting MS (mean age, 38.92 +/- 14.76; 22 men and 24 women) and 46 healthy controls (mean age, 37.04 +/- 15.49; 22 men and 24 women) were enrolled in the study. All MS patients were neurologically examined, and magnetic resonance imaging (MRI) was performed. Clinical data (neuropathic pain, expanded disability status scale (EDSS) score, etc.) and the patients' demographic characteristics were recorded. The serum level of kisspeptin-10 was analyzed by enzyme-linked immunosorbent assay (ELISA) method. Results: The level of kisspeptin-10 was measured as 2.305 +/- 2.781 ng/mL in MS patients and 9.342 +/- 9.483 ng/mL in controls. MS patients had significantly lower kisspeptin-10 levels than controls (P = 0.000). Kisspeptin-10 has the highest diagnostic value [Area under curve (AUC) = 0.881, 95% confidence interval (CI), 0.812-0.950] as cut-off value (2.470), sensitivity (80.40%) and specificity (72.87%) in the MS group. Furthermore, the kisspeptin-10 level was negatively correlated with third ventricle diameter (TVD) (P = 0.048) and vitamin D concentration (P = 0.004). No significant difference was determined between kisspeptin-10 and other clinical parameters. Conclusion: As a potential prognostic biomarker, serum kisspeptin-10 level was significantly lower in patients with MS than in those without. Moreover, we observed negative correlations between vitamin D, TVD size, and kisspeptin-10. We think comprehensive studies are needed to verify and elucidate this issue.en_US
dc.identifier.doi10.1556/2060.2021.00179
dc.identifier.endpage260en_US
dc.identifier.issn2498-602X
dc.identifier.issue2en_US
dc.identifier.pmid34138749en_US
dc.identifier.scopus2-s2.0-85125089861en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://doi.org/10.1556/2060.2021.00179
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15487
dc.identifier.volume108en_US
dc.identifier.wosWOS:000684181000007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofPhysiology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKisspeptin-10en_US
dc.subjectMultiple Sclerosisen_US
dc.subjectNeurological Diseaseen_US
dc.subjectThird Ventricleen_US
dc.subjectVitamin Den_US
dc.titleLevel of kisspeptin-10 in patients with multiple sclerosis and the association between third ventricle diameter size and vitamin D levelen_US
dc.typeArticleen_US

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