A multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001)

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dc.contributor.authorYildirim, Halil Cumhur
dc.contributor.authorKupik, Gulnihan Eren
dc.contributor.authorMustafayev, Teuta Zoto
dc.contributor.authorBerber, Tanju
dc.contributor.authorYavuz, Berrin
dc.contributor.authorCetinayak, Oguz
dc.contributor.authorAkagunduz, Ozlem
dc.date.accessioned2024-02-23T12:11:09Z
dc.date.available2024-02-23T12:11:09Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackgroundWe aimed to evaluate patients with nasopharyngeal carcinoma (NPC) in a nonendemic population. MethodsIn a national, retrospective, multicenteric study, 563 patients treated with intensity modulated radiotherapy at 22 centers between 2015 and 2020 were analyzed. ResultsMedian age was 48 (9-83), age distribution was bimodal, 74.1% were male, and 78.7% were stage III-IVA. Keratinizing and undifferentiated carcinoma rates were 3.9% and 81.2%. Patients were treated with concomitant chemoradiotherapy (48.9%), or radiotherapy combined with induction chemotherapy (25%) or adjuvant chemotherapy (19.5%). After 34 (6-78) months follow-up, 8.2% locoregional and 8% distant relapse were observed. Three-year overall survival was 89.5% and was lower in patients with age >= 50, male sex, keratinizing histology, T4, N3 and advanced stage (III-IVA). ConclusionsPatients with NPC in Turkey have mixed clinical features of both east and west. Survival outcomes are comparable to other reported series; however, the rate of distant metastases seems to be lower.en_US
dc.description.sponsorshipUniversity Grants Commission (UGC), New Delhi [8- 4(57)/2015(MRP/NRCB]; UGC-DAE CSR Kolkata Centreen_US
dc.description.sponsorshipThe author, Ashok K. Pathak, acknowledges financial assistance from the University Grants Commission (UGC), New Delhi (8- 4(57)/2015(MRP/NRCB)). Author, V. K. Singh is very thankful to UGC-DAE CSR Kolkata Centre for partial financial support.en_US
dc.identifier.doi10.1002/hed.27333
dc.identifier.endpage1205en_US
dc.identifier.issn1043-3074
dc.identifier.issn1097-0347
dc.identifier.issue5en_US
dc.identifier.pmid36854873en_US
dc.identifier.scopus2-s2.0-85149269238en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1194en_US
dc.identifier.urihttps://doi.org/10.1002/hed.27333
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10566
dc.identifier.volume45en_US
dc.identifier.wosWOS:000940768500001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHead And Neck-Journal For The Sciences And Specialties Of The Head And Necken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChemoradiotherapyen_US
dc.subjectEbv-Dnaen_US
dc.subjectIntensity-Modulated Radiotherapyen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.subjectNonendemicen_US
dc.titleA multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001)en_US
dc.typeArticleen_US

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