Intravenous paracetamol for relief of pain during transrectal-ultrasound-guided biopsy of the prostate: A prospective, randomized, double-blind, placebo-controlled study

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dc.contributor.authorKilic, Ozcan
dc.contributor.authorAkand, Murat
dc.contributor.authorKulaksizoglu, Haluk
dc.contributor.authorHaliloglu, Ahmet H.
dc.contributor.authorTanidik, Seher
dc.contributor.authorPiskin, Mehmet M.
dc.contributor.authorYurdakul, Talat
dc.date.accessioned2024-02-23T14:13:05Z
dc.date.available2024-02-23T14:13:05Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractTransrectal-ultrasound-guided prostate biopsy (TRUS-PBx) is the standard procedure for diagnosing prostate cancer. The procedure does cause some pain and discomfort; therefore, an adequate analgesia is necessary to ensure patient comfort, which can also facilitate good-quality results. This prospective, randomized, double-blinded, placebo-controlled study aimed to determine if intravenous (IV) paracetamol can reduce the severity of pain associated with TRUS-PBx. The study included 104 patients, scheduled to undergo TRUS-PBx with a suspicion of prostate cancer, that were prospectively randomized to receive either IV paracetamol (paracetamol group) or placebo (placebo group) 30 minutes prior to TRUS-PBx. All patients had 12 standardized biopsy samples taken. Pain was measured using a 10-point visual analog pain scale during probe insertion, during the biopsy procedure, and 1 hour postbiopsy. All biopsies were performed by the same urologist, whereas a different urologist administered the visual analog pain scale. There were not any significant differences in age, prostatespecific antigen level, or prostate volume between the two groups. The pain scores were significantly lower during probe insertion, biopsy procedure, and 1 hour postbiopsy in the paracetamol group than in the placebo group. In conclusion, the IV administration of paracetamol significantly reduced the severity of pain associated with TRUS- PBx. Copyright (C) 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.identifier.doi10.1016/j.kjms.2015.09.003
dc.identifier.endpage579en_US
dc.identifier.issn1607-551X
dc.identifier.issue11en_US
dc.identifier.pmid26678937en_US
dc.identifier.scopus2-s2.0-84949512815en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage572en_US
dc.identifier.urihttps://doi.org/10.1016/j.kjms.2015.09.003
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12295
dc.identifier.volume31en_US
dc.identifier.wosWOS:000366553200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofKaohsiung Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnalgesiaen_US
dc.subjectBiopsyen_US
dc.subjectParacetamolen_US
dc.subjectProstateen_US
dc.subjectTransrectal Ultrasounden_US
dc.titleIntravenous paracetamol for relief of pain during transrectal-ultrasound-guided biopsy of the prostate: A prospective, randomized, double-blind, placebo-controlled studyen_US
dc.typeArticleen_US

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