Silver nanoparticle decorated graphene-based SERS electrode towards procalcitonin detection

Basit Öğe Kaydı
dc.contributor.authorSelimoglu, Faysal
dc.contributor.authorAyhan, Muhammed Emre
dc.date.accessioned2024-02-23T14:16:29Z
dc.date.available2024-02-23T14:16:29Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractMonitoring procalcitonin levels (PCT) is critical for early diagnosis of sepsis, chronic disease, COVID-19 and other time-dependent pathologic cases. In this work, silver nanoparticles (AgNps) doped graphene-based Surface-enhanced Raman scattering (SERS) electrode was demonstrated for the first time to rapid detection of PCT biomarkers. An excellent combination of AgNps and single-layer graphene (SLG) was achieved, resulting in effective SERS enhancement. Due to the smooth and large surface area of SLG, many antibody molecules bind to the surface of SERS electrode and interact with PCT protein. The SERS enhancement factors (EFs) for R6G and PCT protein molecules were calculated to be 1012 and 1.6 x 109, respectively. The limits of detection (LODs) for R6G and PCT protein molecules were reported to be 10-13 M and 4 ngmL-1, respectively. These high EFs and lower LODs indicate that the fabricated AgNp/Gr@ ITO SERS electrodes have perfect SERS performance. SERS studies showed that there is a perfect interaction between PCT protein and AgNps and SLG, which leads to the enhancement of electromagnetic mechanism (EM) and chemical mechanism (CM) in the fabricated SERS ma-terials. The developed eco-friendly SERS platform can provide reliable and sensitive test results, faster analysis compared to conventional biosensors, mobile applications and cost-effective clinical management.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit at Necmettin Erbakan University [201219006]en_US
dc.description.sponsorshipThis research has been supported by the Scientific Research Projects Coordination Unit at Necmettin Erbakan University with Grant No: 201219006.en_US
dc.identifier.doi10.1016/j.vibspec.2023.103539
dc.identifier.issn0924-2031
dc.identifier.issn1873-3697
dc.identifier.scopus2-s2.0-85159582886en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.vibspec.2023.103539
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12670
dc.identifier.volume126en_US
dc.identifier.wosWOS:001001354800001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofVibrational Spectroscopyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgnpsen_US
dc.subjectCvd Grapheneen_US
dc.subjectSepsisen_US
dc.subjectSersen_US
dc.subjectProcalcitoninen_US
dc.titleSilver nanoparticle decorated graphene-based SERS electrode towards procalcitonin detectionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu