Evaluation of the effectiveness of biodegradable electrospun caprolactone and poly(lactic acid-e-caprolactone) nerve conduits for peripheral nerve regenerations in a rat sciatic nerve defect model

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dc.contributor.authorDadaci, Mehmet
dc.contributor.authorKaragulle, Nimet
dc.contributor.authorSonmez, Erhan
dc.contributor.authorDadaci, Zeynep
dc.contributor.authorIsci, Evren Tevfik
dc.contributor.authorInce, Bilsev
dc.contributor.authorVargel, Ibrahim
dc.date.accessioned2024-02-23T14:37:22Z
dc.date.available2024-02-23T14:37:22Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: The aim of this study was to compare electrospun caprolactone (EC) and poly(lactic acid-epsilon-caprolactone) (PLCL) nerve conduits with nerve graft in a rat sciatic nerve defect model. Materials and methods: A total of 32 male Wistar albino rats were divided into 4 groups, with 8 rats in each group. A nerve defect of 1 cm was constructed in the left sciatic nerve of the rats. These defects were left denuded in the sham group, and reconstructed with nerve grafts, PLCL, and EC nerve conduits in the other groups. After 3 months, nerve regenerations were evaluated macroscopically, microscopically, and electrophysiologically. The numbers of myelinated axons in the cross-sections of the nerves were compared between the groups. Results: Macroscopically, all nerve coaptations were intact and biodegradation was detected in nerve conduits. Electromyographic assessment and count of myelinated axons in the cross-sections of the nerves displayed the best regeneration in the nerve graft group (P < 0.001) and similar results were obtained in the PLCL and EC nerve conduit groups (P = 0.79). Light and electron microscopy studies demonstrated nerve regeneration in both nerve conduit groups. Conclusion: EC nerve conduits and PLCL nerve conduits yielded similar results and may be alternatives to nerve grafts as they biodegrade.en_US
dc.identifier.doi10.3906/sag-1412-110
dc.identifier.endpage548en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid27511522en_US
dc.identifier.scopus2-s2.0-84958559541en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1412-110
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16071
dc.identifier.volume46en_US
dc.identifier.wosWOS:000370271100044en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNerve Regenerationen_US
dc.subjectNerve Graften_US
dc.subjectElectrospun Caprolactone Nerve Conduitsen_US
dc.subjectPoly(Dl-Lactide-Epsilon-Caprolactone) Nerve Conduitsen_US
dc.titleEvaluation of the effectiveness of biodegradable electrospun caprolactone and poly(lactic acid-e-caprolactone) nerve conduits for peripheral nerve regenerations in a rat sciatic nerve defect modelen_US
dc.typeArticleen_US

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