Beta-Hydroxy-Beta-Methyl-Butyrate, L-glutamine, and L-arginine Supplementation Improves Radiation-Induce Acute Intestinal Toxicity

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dc.contributor.authorYavas, Cagdas
dc.contributor.authorYavas, Guler
dc.contributor.authorCelik, Esin
dc.contributor.authorBuyukyoruk, Ahmet
dc.contributor.authorBuyukyoruk, Cennet
dc.contributor.authorYuce, Deniz
dc.contributor.authorAta, Ozlem
dc.date.accessioned2024-02-23T14:20:43Z
dc.date.available2024-02-23T14:20:43Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractWe aimed to evaluate effects of beta-hydroxy-beta-methylbutyrate, L-glutamine, and L-arginine (HMB/GLN/ARG) on radiation-induced acute intestinal toxicity. Forty rats were divided into four groups: group (G) 1 was defined as control group, and G2 was radiation therapy (RT) control group. G3 and G4 were HMB/GLN/ARG control and RT plus HMB/GLN/ARG groups, respectively. HMB/GLN/ARG started from day of RT and continued until the animals were sacrificed 10 days after RT. The extent of surface epithelium smoothing, villous atrophy, lamina propria inflammation, cryptitis, crypt distortion, regenerative atypia, vascular dilatation and congestion, and fibrosis were quantified on histological sections of intestinal mucosa. Statistical analyses were performed using the analysis of variance (ANOVA) test. There were significant differences between study groups regarding extent of surface epithelium smoothing, villous atrophy, lamina propria inflammation, cryptitis and crypt distortion, regenerative atypia, vascular dilatation and congestion, and fibrosis (p values were 0.019 for fibrosis, <.001 for the others). Pair-wise comparisons revealed significant differences regarding surface epithelium smoothing, villous atrophy, lamina propria inflammation, cryptitis, vascular dilatation, and congestion between G2 and G4 (p values were <.001, .033, <.001, .007, and <.001, respectively). Fibrosis score was significantly different only between G1 and G2 (p = .015). Immunohistochemical TGF-beta score of G2 was significantly higher than G1 and G3 (p values were .006 and .017, respectively). There was no difference between TGF-beta staining scores of G2 and G4. Concomitant use of HMB/GLN/ARG appears to ameliorate radiation-induced acute intestinal toxicity; however, this finding should be clarified with further studies.en_US
dc.description.sponsorshipSelcuk University [14401052]en_US
dc.description.sponsorshipThis work was supported by Selcuk University (Project number: 14401052). There is no role of study sponsors in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.en_US
dc.identifier.doi10.1080/19390211.2018.1472709
dc.identifier.endpage591en_US
dc.identifier.issn1939-0211
dc.identifier.issn1939-022X
dc.identifier.issue5en_US
dc.identifier.pmid29969326en_US
dc.identifier.scopus2-s2.0-85049593670en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage576en_US
dc.identifier.urihttps://doi.org/10.1080/19390211.2018.1472709
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13264
dc.identifier.volume16en_US
dc.identifier.wosWOS:000482425900008en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Dietary Supplementsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestineen_US
dc.subjectL-Arginineen_US
dc.subjectL-Glutamineen_US
dc.subjectRadiation-Enteropathyen_US
dc.subjectBeta-Hydroxy-Beta-Methylbutyrateen_US
dc.titleBeta-Hydroxy-Beta-Methyl-Butyrate, L-glutamine, and L-arginine Supplementation Improves Radiation-Induce Acute Intestinal Toxicityen_US
dc.typeArticleen_US

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