Expression of the angiogenesis markers endocan in Cushing's syndrome due to cortisol producing adenoma

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dc.contributor.authorCan, Mustafa
dc.contributor.authorKocabas, Muhammet
dc.contributor.authorKarakose, Melia
dc.contributor.authorEsen, Haci Hasan
dc.contributor.authorKulaksizoglu, Mustafa
dc.contributor.authorKarakurt, Feridun
dc.date.accessioned2024-02-23T13:59:44Z
dc.date.available2024-02-23T13:59:44Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractPurpose In this study, we aimed to investigate the endocan expression in tissue samples of patients diagnosed with Cushing's syndrome (CS) due to Cortisol-Producing-Adenoma (CPA) and compare it with normal adrenal cortex tissue, and also to evaluate the correlations of endocan expression with clinical and histopathological features. Methods 11 patients who were operated for CS due to CPA between 2009-2021 and 14 control subjects with normal adrenal cortex were included in the study. Demographic, laboratory and clinicopathological data of the patients were recorded. Sections of 4-5 mu m thickness were taken from paraffin blocks of patients diagnosed with CS due to CPA and control subjects with normal adrenal cortex tissue. The sections were then stained in a closed system automatic immunohistochemical staining device to perform immunohistochemical analysis. The endocan positive grade were determined based on the proportion of stained cells on a scale of negative to strong. Results The number of subjects with positive endocan expression and the mean endocan expression level in the CS group were significantly higher than the control group (p = 0.005, p < 0.001, respectively). No correlation was found between endocan expression and clinical and histopathological features. Conclusion According to the results of our study, endocan overexpression in CPA tissues may be related to the hormonal functionality of CPA.en_US
dc.identifier.doi10.1007/s12020-022-03250-1
dc.identifier.endpage558en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue3en_US
dc.identifier.pmid36350461en_US
dc.identifier.scopus2-s2.0-85141622007en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage554en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-022-03250-1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11302
dc.identifier.volume79en_US
dc.identifier.wosWOS:000880570200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCushing's Syndromeen_US
dc.subjectCortisol-Producing-Adenomaen_US
dc.subjectEndocanen_US
dc.subjectAdrenal Cortexen_US
dc.titleExpression of the angiogenesis markers endocan in Cushing's syndrome due to cortisol producing adenomaen_US
dc.typeArticleen_US

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