The Relationship of Periaortic Fat Thickness and Cardiovascular Risk Factors in Children with Turner Syndrome

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dc.contributor.authorAkyurek, Nesibe
dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorEklioglu, Beray Selver
dc.contributor.authorAlp, Hayrullah
dc.date.accessioned2024-02-23T13:43:35Z
dc.date.available2024-02-23T13:43:35Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractChildren with Turner syndrome (TS) have a broad range of later health problems, including an increased risk of cardiovascular morbidity and mortality. The aim of this study was to evaluate the relationship between periaortic fat thickness (PAFT) and metabolic and cardiovascular profiles in children with TS. Twenty-nine TS and 29 healthy children and adolescents were enrolled in the study. Anthropometric measurements, pubertal staging, and blood pressure measurements were performed. Fasting serum glucose, insulin, and lipid profile were measured. Periaortic fat thickness was measured using an echocardiography method, which has not previously been applied in children with TS. No difference was found between TS and control subject (CS) in age, weight, waist/hip ratio, HDL cholesterol and LDL cholesterol levels. However, in TS subjects, total cholesterol (p = 0.045) was greater than that in controls. It was determined that 13.7 % (N: 4) of TS subjects had dyslipidemia. Mean fasting glucose, fasting insulin, QUICK-I, HOMA, and FGIR index were similar in TS and in CS, whereas 17.2 % (N: 5) of TS subjects had insulin resistance (IR) and 13.7 % (N: 4) had impaired glucose tolerance. Six subjects (20.6 %) were diagnosed as hypertensive. Periaortic fat thickness was significantly higher in the TS group (p < 0.001) (0.1694 +/- A 0.025 mm in the TS group and 0.1416 +/- A 0.014 mm in the CS group) In children with TS, PAFT was positively correlated with fasting insulin, body mass index, and diastolic blood pressure. Our results provide additional evidence for the presence of subclinical cardiovascular disease in TS. In addition to existing methods, we recommend the measurement of periaortic fat thickness in children with TS to reveal the presence of early atherosclerosis.en_US
dc.identifier.doi10.1007/s00246-015-1098-4
dc.identifier.endpage929en_US
dc.identifier.issn0172-0643
dc.identifier.issn1432-1971
dc.identifier.issue5en_US
dc.identifier.pmid25601134en_US
dc.identifier.scopus2-s2.0-84939999287en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage925en_US
dc.identifier.urihttps://doi.org/10.1007/s00246-015-1098-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10861
dc.identifier.volume36en_US
dc.identifier.wosWOS:000354477000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeriaortic Fat Thicknessen_US
dc.subjectTurner Syndromeen_US
dc.subjectCardiovascular Diseaseen_US
dc.titleThe Relationship of Periaortic Fat Thickness and Cardiovascular Risk Factors in Children with Turner Syndromeen_US
dc.typeArticleen_US

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