Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris

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dc.contributor.authorTuncez Akyurek, Fatma
dc.contributor.authorSaylam Kurtipek, Gulcan
dc.contributor.authorKurku, Huseyin
dc.contributor.authorAkyurek, Fikret
dc.contributor.authorUnlu, Ali
dc.contributor.authorAbusoglu, Sedat
dc.contributor.authorAtaseven, Arzu
dc.date.accessioned2024-02-23T14:24:29Z
dc.date.available2024-02-23T14:24:29Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractBackground Acne vulgaris is a common skin disease in adolescents known to be associated with oxidative stress. However, the number of studies in which oxidative stress and antioxidants are evaluated together is limited. Aims In this study, we aimed to investigate L-arginine/nitric oxide (NO) pathway metabolites, ischemia-modified albumin (IMA), and vitamin A and E levels in patients with acne and its association with disease severity. Patients/Methods Ninety patients with acne and 30 healthy adults were included in the study. The serum levels ofL-arjinin, L-arginine metabolites, IMA, and vitamins A and E measured in the patient and control groups. Results Asymmetric dimethylarginine (ADMA), LNG-monomethyl-L-arginine (L-NMMA) and symmetric dimethylarginine (SDMA), and IMA levels were significantly higher in the patients with acne than in the control group (P < .05). The L-arginine/ADMA ratio and citrulline and vitamin A levels were significantly lower in patients with acne than those of the controls (P < .05). ADMA and IMA plasma levels were increased in parallel with the disease severity (P < .05). L-arginine/ADMA ratio, L-arginine, citrulline, and vitamin A plasma levels decreased as the disease became severe (P < .05). Although L-arginine and vitamin E levels were lower in the patient group compared to the control group, the difference was not statistically significant (P > .05). Conclusion These results suggest that IMA and L-arginine-NO pathway associated with ischemia and oxidative stress may play an important role in the pathogenesis and progression of acne vulgaris.en_US
dc.description.sponsorshipKonya Training and Research HospitalEducation and Research Fund [57/4]en_US
dc.description.sponsorshipKonya Training and Research HospitalEducation and Research Fund, Grant/Award Number: 57/4en_US
dc.identifier.doi10.1111/jocd.13590
dc.identifier.endpage3413en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue12en_US
dc.identifier.pmid32623816en_US
dc.identifier.scopus2-s2.0-85088235605en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3408en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.13590
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13955
dc.identifier.volume19en_US
dc.identifier.wosWOS:000550504600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcne Vulgarisen_US
dc.subjectAsymmetric Dimethylarginine (Adma)en_US
dc.subjectIschemia Modified Albumin (Ima)en_US
dc.subjectOxidative Stressen_US
dc.subjectVitamin A And Een_US
dc.titleAssessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgarisen_US
dc.typeArticleen_US

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