The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis

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dc.contributor.authorCakir, Ozlem Ozer
dc.contributor.authorToker, Aysun
dc.contributor.authorAtaseven, Huseyin
dc.contributor.authorDemir, Ali
dc.contributor.authorPolat, Hakki
dc.date.accessioned2024-02-23T14:44:57Z
dc.date.available2024-02-23T14:44:57Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Acute hepatitis is acute inflammation of liver elicited by a large number of causes. It sometimes spontaneously recovers, sometimes may progress to chronic hepatitis. LiverFatty Acid Binding Protein (L-FABP) is a small protein that is abundant in hepatocytes, and which binds most of the longchain fatty acids present in the cytosol. Aim: The present study aimed to investigate the levels of serum and urine L-FABP in acute hepatitis and diagnostic value of serum and urine L-FABP levels in patients with acute hepatitis. Materials and Methods: The present study included a total of 85 patients. Total number of patients with acute hepatitis were 17 (five of acute hepatitis B, one of acute hepatitis A, two of acute hepatitis C, five of autoimmune hepatitis and four of toxic hepatitis), 19 of hepatic encephalopathy, 29 of liver cirrhosis, and 20 controls were included. Serum and urinary L-FABP levels were analyzed by the Enzyme-Linked Immunosorbent Assay (ELISA). Results: Serum L-FABP levels were 9110 +/- 3352.5, 9410 +/- 1355, 9715 +/- 2462 and 3672 +/- 982.5 ng/l in patients with acute hepatitis, hepatic encephalopathy and cirrhosis and control subjects, respectively. There were statistically significant positive correlations between serum levels of L-FABP and Aspartate Aminotransferases (AST), Alanine Aminotransferases (ALT), Creatinine (Cre) and Gamma Glutamyl Transferases (GGT) (p<0.001, p<0.001, p<0.001 and p<0.001, respectively). While the cut-off value of serum L-FABP for all of the patients was 5183 ng/ l {p<0.001 and Area Under Curve (AUC)0.985}, the sensitivity and specificity were 95.4% and 100%, respectively. Positive and negative predictive values for serum L- FABP were 100% and 87%, respectively. Conclusion: Serum and urine L-FABP may be a new diagnostic marker for liver damage in patients with acute hepatitis. However, our study showed that except of aminotransferases, L-FABP should be used for diagnosis of liver damage in patients with acute hepatitis, chronic hepatitis and also cirrhosis.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Funden_US
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University Scientific Research Projects Fund.en_US
dc.identifier.doi10.7860/JCDR/2017/24958.9621
dc.identifier.endpageOC21en_US
dc.identifier.issn2249-782X
dc.identifier.issn0973-709X
dc.identifier.issue4en_US
dc.identifier.pmid28571184en_US
dc.identifier.scopus2-s2.0-85016946110en_US
dc.identifier.startpageOC17en_US
dc.identifier.urihttps://doi.org/10.7860/JCDR/2017/24958.9621
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17160
dc.identifier.volume11en_US
dc.identifier.wosWOS:000398027300071en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPremchand Shantidevi Research Foundationen_US
dc.relation.ispartofJournal Of Clinical And Diagnostic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCirrhosisen_US
dc.subjectHepatic Encephalopathyen_US
dc.subjectSteatohepatitisen_US
dc.titleThe Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitisen_US
dc.typeArticleen_US

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