Are decreased cocaine- and amphetamine regulated transcript and Agouti-related peptide levels associated Eating behavior in medication-free children with attention deficit and hyperactivity disorder?

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dc.contributor.authorTezcan, Mustafa Esad
dc.contributor.authorUgur, Cuneyt
dc.contributor.authorCan, Ummugulsum
dc.contributor.authorUcak, Ekrem Furkan
dc.contributor.authorEkici, Fatih
dc.contributor.authorDuymus, Fahrettin
dc.contributor.authorKorucu, Agah Tugrul
dc.date.accessioned2024-02-23T14:13:36Z
dc.date.available2024-02-23T14:13:36Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractThis study aimed to investigate plasma levels of cocaine-and amphetamine-regulated transcript (CART), agouti-related protein (AgRP), cholecystokinin (CCK) and peptide YY (PYY) and their relationship with eating behaviors among children with attention deficit hyperactivity disorder (ADHD) and healthy controls. A total of 94 medication-free children with ADHD and 82 controls aged 8-14 years were included in this study. The Plasma levels of CART, AgRP, CCK and PYY were measured using enzyme-linked immunosorbent assay kits. The Chil-dren's Eating Behavior Questionnaire (CEBQ) was used to assess eating behaviors in children. CART and AgRP levels were found to be significantly lower in the ADHD group than in the control group, while CCK levels were found to be significantly higher in the ADHD group than in the control group. However, there was no significant difference in PYY levels between the groups. Compared to controls, those with ADHD demonstrated significantly higher scores on the CEBQ subscales of food responsiveness, emotional overeating, desire to drink, enjoyment of food, and food fussiness, and significantly lower scores on the slowness of eating subscale. CART was signifi-cantly correlated with emotional overeating and enjoyment of food scores, while AgRP was significantly correlated with emotional undereating scores. Covariance analysis was performed by controlling potential confounders such as body mass index, age and sex, and the results were found to be unchanged. It was concluded that CART, AgRP, and CCK may play a potential role in the pathogenesis of ADHD.en_US
dc.identifier.doi10.1016/j.pnpbp.2023.110907
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.pmid38043633en_US
dc.identifier.scopus2-s2.0-85179076612en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2023.110907
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12496
dc.identifier.volume129en_US
dc.identifier.wosWOS:001134136200001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress In Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAttention Deficit Hyperactivity Disorderen_US
dc.subjectAppetite Regulationen_US
dc.subjectCarten_US
dc.subjectAgrpen_US
dc.subjectPeptide Yyen_US
dc.subjectCcken_US
dc.titleAre decreased cocaine- and amphetamine regulated transcript and Agouti-related peptide levels associated Eating behavior in medication-free children with attention deficit and hyperactivity disorder?en_US
dc.typeArticleen_US

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