Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus

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dc.contributor.authorDemirtas, Levent
dc.contributor.authorGuclu, Aydin
dc.contributor.authorErdur, Fatih Mehmet
dc.contributor.authorAkbas, Emin Murat
dc.contributor.authorOzcicek, Adalet
dc.contributor.authorOnk, Didem
dc.contributor.authorTurkmen, Kultigin
dc.date.accessioned2024-02-23T14:37:43Z
dc.date.available2024-02-23T14:37:43Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractThe prevalence of diabetes mellitus (DM) is increasing secondary to increased consumption of food and decreased physical activity worldwide. Hyperglycaemia, insulin resistance and hypertrophy of pancreatic beta cells occur in the early phase of diabetes. However, with the progression of diabetes, dysfunction and loss of beta cells occur in both types 1 and 2 DM. Programmed cell death also named apoptosis is found to be associated with diabetes, and apoptosis of beta cells might be the main mechanism of relative insulin deficiency in DM. Autophagic cell death and apoptosis are not entirely distinct programmed cell death mechanisms and share many of the regulator proteins. These processes can occur in both physiologic and pathologic conditions including DM. Besides these two important pathways, endoplasmic reticulum (ER) also acts as a cell sensor to monitor and maintain cellular homeostasis. ER stress has been found to be associated with autophagy and apoptosis. This review was aimed to describe the interactions between apoptosis, autophagy and ER stress pathways in DM.en_US
dc.identifier.doi10.4103/0971-5916.200887
dc.identifier.endpage524en_US
dc.identifier.issn0971-5916
dc.identifier.pmid28256459en_US
dc.identifier.scopus2-s2.0-85014122814en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage515en_US
dc.identifier.urihttps://doi.org/10.4103/0971-5916.200887
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16216
dc.identifier.volume144en_US
dc.identifier.wosWOS:000395983100006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectCell Survival And Deathen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectEndoplasmic Reticulum Stressen_US
dc.titleApoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitusen_US
dc.typeReview Articleen_US

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