The role of nitric oxide on the responses of curcumin-treated rat aorta

Basit Öğe Kaydı
dc.contributor.authorNurullahoglu-Atalik, K. E.
dc.contributor.authorGokbel, H.
dc.contributor.authorOz, M.
dc.contributor.authorOkudan, N.
dc.contributor.authorBelviranli, M.
dc.contributor.authorEsen, H.
dc.date.accessioned2024-02-23T14:37:57Z
dc.date.available2024-02-23T14:37:57Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractObjectives: The aim of the present study was to evaluate the influence of endothelial nitric oxide (NO) on the vascular responses of curcumin-treated rats. Methods: The experimental groups included the control and curcumin-treated (200 mg/kg/day, p.o., for 4 weeks) group. The concentration response curves to receptor-dependent agent 5-hydroxytryptamine (5-HT; 10(-9)-3x10(-4) M) and receptor-independent agent potassium chloride (KCl; 5-100 mM) were observed. Results: The concentration response curves to 5-HT and KCl shifted to the right and the maximal response was significantly decreased in the curcumin-treated rat aortas. A pretreatment of rings with L-NAME (a NOS inhibitor, 10(-4) M) increased both the sensitivity and maximal response to only 5-HT. No apparent histological changes were demonstrated in smooth muscle and connective tissue layers in the aortas of the control and curcumin-treated rat preparations. Conclusion: The results of the present study suggest that NO release from endothelial cells modulates curcumin-treated rat aorta responses to 5-HT, but not to KCl (Tab. 2, Fig. 4, Ref. 25). Full Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2012_063
dc.identifier.endpage273en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5en_US
dc.identifier.pmid22616583en_US
dc.identifier.scopus2-s2.0-84871769533en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage270en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2012_063
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16305
dc.identifier.volume113en_US
dc.identifier.wosWOS:000304794900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAortaen_US
dc.subjectCurcumineen_US
dc.subjectContractionsen_US
dc.subjectSerotoninen_US
dc.subjectKclen_US
dc.subjectNitric Oxideen_US
dc.titleThe role of nitric oxide on the responses of curcumin-treated rat aortaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu