Is prenatal testosterone-estrogen balance associated with psoriasis?

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dc.contributor.authorOzer, Ilkay
dc.contributor.authorTemiz, Selami A.
dc.contributor.authorAtaseven, Arzu
dc.contributor.authorDursun, Recep
dc.contributor.authorUyar, Mehmet
dc.contributor.authorOzer, Mustafa
dc.date.accessioned2024-02-23T14:24:06Z
dc.date.available2024-02-23T14:24:06Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractThe etiopathogenesis of psoriasis is not understood; however, psoriasis is affected by hormones, particularly the sex steroids. The second-to-fourth digit (2D:4D) ratio, which is an indicator of prenatal sex hormone balance, has been studied in various diseases that are affected by hormones. A total of 369 individuals comprising 172 patients with psoriasis and 197 healthy volunteers were included in the study. Patients with psoriasis were divided into type-1 and type-2, according to age of onset and family history. The 2D:4D ratio of both hands was recorded for all participants. Females in the psoriasis group had a lower 2D:4D ratio in both hands compared with those in the control group, with no significant difference. Males in the psoriasis group had a higher 2D:4D ratio for both hands compared with those in the control group (P= .009 andP < .001 for the right and left hands, respectively). Further, male patients with type-1 psoriasis had a lower 2D:4D ratio compared to those with type-2 psoriasis. Our results suggest that an alteration of the estrogen-testosterone balance due to prenatal testosterone activity is an independent predisposing factor for psoriasis in males.en_US
dc.identifier.doi10.1111/dth.14213
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue6en_US
dc.identifier.pmid32820834en_US
dc.identifier.scopus2-s2.0-85090302151en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/dth.14213
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13823
dc.identifier.volume33en_US
dc.identifier.wosWOS:000566805900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammatory Disordersen_US
dc.subjectPsoriasisen_US
dc.titleIs prenatal testosterone-estrogen balance associated with psoriasis?en_US
dc.typeArticleen_US

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