Corneal Confocal Microscopy to Image Small Nerve Fiber Degeneration: Ophthalmology Meets Neurology

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dc.contributor.authorPetropoulos, Ioannis N.
dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorFerdousi, Maryam
dc.contributor.authorKalteniece, Alise
dc.contributor.authorAzmi, Shazli
dc.contributor.authorD'Onofrio, Luca
dc.contributor.authorLim, Sze Hway
dc.date.accessioned2024-02-23T14:34:59Z
dc.date.available2024-02-23T14:34:59Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractNeuropathic pain has multiple etiologies, but a major feature is small fiber dysfunction or damage. Corneal confocal microscopy (CCM) is a rapid non-invasive ophthalmic imaging technique that can image small nerve fibers in the cornea and has been utilized to show small nerve fiber loss in patients with diabetic and other neuropathies. CCM has comparable diagnostic utility to intraepidermal nerve fiber density for diabetic neuropathy, fibromyalgia and amyloid neuropathy and predicts the development of diabetic neuropathy. Moreover, in clinical intervention trials of patients with diabetic and sarcoid neuropathy, corneal nerve regeneration occurs early and precedes an improvement in symptoms and neurophysiology. Corneal nerve fiber loss also occurs and is associated with disease progression in multiple sclerosis, Parkinson's disease and dementia. We conclude that corneal confocal microscopy has good diagnostic and prognostic capability and fulfills the FDA criteria as a surrogate end point for clinical trials in peripheral and central neurodegenerative diseases.en_US
dc.identifier.doi10.3389/fpain.2021.725363
dc.identifier.issn2673-561X
dc.identifier.pmid35295436en_US
dc.identifier.scopus2-s2.0-85128309870en_US
dc.identifier.urihttps://doi.org/10.3389/fpain.2021.725363
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15840
dc.identifier.volume2en_US
dc.identifier.wosWOS:001005360800001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Pain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCorneal Confocal Microscopyen_US
dc.subjectNeurodegenerationen_US
dc.subjectPainful Neuropathyen_US
dc.subjectDiabetesen_US
dc.subjectBiomarkeren_US
dc.titleCorneal Confocal Microscopy to Image Small Nerve Fiber Degeneration: Ophthalmology Meets Neurologyen_US
dc.typeReview Articleen_US

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