The effects of selenium and vitamin E on lung tissue in rats with sepsis

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dc.contributor.authorAtli, Mustafa
dc.contributor.authorErikoglu, Mehmet
dc.contributor.authorKaynak, Adnan
dc.contributor.authorEsen, Haci H.
dc.contributor.authorKurban, Sevil
dc.date.accessioned2024-02-23T14:45:34Z
dc.date.available2024-02-23T14:45:34Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractPurpose: In this study we examined the ability of selenium and vitamin E to prevent sepsis-induced changes in lung tissue. Methods: Fifty rats were divided into five groups: Group 1: Control group; Group 2: Sepsis group. In this group only cecal ligation and perforation (CLP) was performed. Group 3: Selenium group. An intraperitoneal dose of 100 mu g selenium was given for the first two days followed by a daily dose of 40 mu g for the next five days. CLP was performed the following day. Group 4: Selenium and vitamin E group. In addition to selenium, vitamin E was given intramuscularly in a dose of 250 mg/kg/day for seven days. CLP was performed the following day. Group 5: Vitamin E group. Vitamin E was given intramuscularly in a dose of 250 mg/kg/day for seven days. CLP was performed the following day. Results: There were significant differences between Group 2 and all other groups in terms of blood gas values (pH, pCO2, SaO2), and leukocyte, C-reactive protein (CRP) and glutathione peroxidase levels (p< 0.005). There was no statistically significant difference between groups 3, 4 and 5 in terms of histopathological changes in lung tissue (p> 0.05), but all groups were significantly different compared with Group 2 (p< 0.05). Conclusion: Sepsis-induced lung tissue damage can be reduced or prevented by pretreatment with of selenium and/or vitamin E in a rat model.en_US
dc.identifier.endpageE54en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue2en_US
dc.identifier.pmid22469104en_US
dc.identifier.scopus2-s2.0-84863749900en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE48en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17501
dc.identifier.volume35en_US
dc.identifier.wosWOS:000302966500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical And Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleThe effects of selenium and vitamin E on lung tissue in rats with sepsisen_US
dc.typeArticleen_US

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