Comparison of Prognostic Factors in Glioblastoma Patients with Short- and Long-term Survival

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dc.contributor.authorYavuz, Berrin Benli
dc.contributor.authorKanyilmaz, Gul
dc.contributor.authorAktan, Meryem
dc.date.accessioned2024-02-23T14:41:38Z
dc.date.available2024-02-23T14:41:38Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE Glioblastoma (GBM) is the most aggressive primary brain tumor. Despite all treatments, very few have long-term survival. This retrospective study aimed to investigate the clinicopathological features, treatment modalities, and factors affecting survival in GBM patients with short-and long-term survival. METHODS Data from 217 GBM patients who received radiotherapy (RT) between 2010 and 2021 were analyzed. The patients were divided into two groups: short (<6 months) and long (>2 years) living groups. Treatment, patient, and tumor characteristics were evaluated. RESULTS While 37 (17.1%) of 217 patients included in the group lived <6 months, 49 (22.6%) were in the group that lived longer than 2 years. In the long-living group, being under 65 years of age, having better performance, performing total excision, applying conventional RT, and receiving adjuvant chemotherapy (CT) detected more frequently. The regression test showed that young age, good performance, and receiving conventional RT and adjuvant chemotherapy (CT) were independently associated with survival. CONCLUSION It was observed that patients who lived longer were frequently young and well-performing ones who underwent wide excision and received conventional RT and adjuvant CT. By estimating the pre-treatment survival, treatment and support plans can be made accordingly.en_US
dc.identifier.doi10.5505/tjo.2023.4057
dc.identifier.endpage398en_US
dc.identifier.issn1300-7467
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85178959349en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage392en_US
dc.identifier.urihttps://doi.org/10.5505/tjo.2023.4057
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16942
dc.identifier.volume38en_US
dc.identifier.wosWOS:001074076700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal Of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlioblastomaen_US
dc.subjectLong-Term Survivalen_US
dc.subjectPrognosisen_US
dc.subjectRadiotherapyen_US
dc.titleComparison of Prognostic Factors in Glioblastoma Patients with Short- and Long-term Survivalen_US
dc.typeArticleen_US

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