Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues

Basit Öğe Kaydı
dc.contributor.authorAricigil, Mitat
dc.contributor.authorDundar, Mehmet Akif
dc.contributor.authorYucel, Abitter
dc.contributor.authorArbag, Hamdi
dc.contributor.authorArslan, Abdullah
dc.contributor.authorAktan, Meryem
dc.contributor.authorFindik, Sidika
dc.date.accessioned2024-02-23T14:02:21Z
dc.date.available2024-02-23T14:02:21Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractIntroduction: To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications. Objective: In this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day. Methods: Thirty-two Wistar Albino rats were divided into four groups. The control group was given no treatment, the hyperbaric oxygen group was given only hyperbaric oxygen therapy, the radiotherapy group was given only radiotherapy, and the radiotherapy plus hyperbaric oxygen group was given both treatments on the same day. Results: Histopathological and biochemical evaluations of specimens were performed. Serum tumor necrosis factor-alpha, interleukin-1 beta, and tissue inflammation levels were significantly higher in the radiotherapy group than in the radiotherapy plus hyperbaric oxygen group, whereas interteukin-10 was higher in the radiotherapy plus hyperbaric oxygen group. Conclusion: When radiotherapy and hyperbaric oxygen are administered on the same day, inflammatory cytokines and tissue inflammation can be reduced in an early period of radiation injury. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.en_US
dc.identifier.doi10.1016/j.bjorl.2017.02.001
dc.identifier.endpage211en_US
dc.identifier.issn1808-8694
dc.identifier.issn1808-8686
dc.identifier.issue2en_US
dc.identifier.pmid28341337en_US
dc.identifier.scopus2-s2.0-85015995823en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage206en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjorl.2017.02.001
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11665
dc.identifier.volume84en_US
dc.identifier.wosWOS:000428175200011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacialen_US
dc.relation.ispartofBrazilian Journal Of Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectNeck Radiotherapyen_US
dc.subjectInflammationen_US
dc.titleAnti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissuesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu