Comparison of retrograde intrarenal stone surgery with and without a ureteral access sheath using kidney injury molecule-1 (KIM-1) levels: a prospective randomized study

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dc.contributor.authorEcer, Gokhan
dc.contributor.authorSonmez, Mehmet Giray
dc.contributor.authorAyd, Arif
dc.contributor.authorTopcu, Cemile
dc.contributor.authorAlalam, Haider Nihad Izaddin
dc.contributor.authorGuven, Selcuk
dc.contributor.authorBalasar, Mehmet
dc.date.accessioned2024-02-23T13:43:34Z
dc.date.available2024-02-23T13:43:34Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe objective is to compare patients who underwent retrograde intrarenal surgery with and without a ureteral access sheath (UAS) using kidney injury molecule-1 (KIM-1) levels. We also examined the difference in kidney damage between standard and dual lumen UAS. Sixty patients diagnosed with kidney stones and scheduled for RIRS were randomized into three groups: RIRS without UAS (Group 1), 11Fr/13Fr Boston scientific Navigator (TM) UAS (Group 2), and 11Fr/13Fr dual lumen ClearPetra (TM) UAS (Group 3). Data were prospectively collected in consecutive patients. Urine KIM-1/Cr levels were measured preoperatively, at postoperative 4 h, and on a postoperative day 14. Stone size, location, number, pre- and postoperative stent use, operation time, stone-free rate (SFR), post-ureteroscopic lesion scale (PULS) grade, hospitalization duration, and complications were recorded. There was no significant difference in demographical parameters and preoperative KIM-1/Cr levels among the groups. Postoperative 4th-hour urine KIM-1/Cr levels were higher in patients without UAS than patients with UAS (1.86, 0.67, 0.63 Groups 1, 2, 3, respectively). In comparing group 1 with groups 2 and 3 separately, Group 1 had a statistically significantly higher value than both groups (p = 0.002, p = 0.001, respectively). According to UAS type, there was no significant difference between groups 2 and 3. The use of UAS during RIRS has been shown to reduce kidney injury in the evaluation with KIM-1. Different UAS types on kidney injury and which one can protect the kidneys more during the procedure; will be elucidated by prospective randomized studies involving larger patient groups and UAS types.en_US
dc.identifier.doi10.1007/s00240-022-01345-y
dc.identifier.endpage633en_US
dc.identifier.issn2194-7228
dc.identifier.issn2194-7236
dc.identifier.issue5en_US
dc.identifier.pmid35802150en_US
dc.identifier.scopus2-s2.0-85133599773en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage625en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-022-01345-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10855
dc.identifier.volume50en_US
dc.identifier.wosWOS:000822259500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofUrolithiasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFlexible Ureterorenoscopyen_US
dc.subjectKidney Injury Molecule-1en_US
dc.subjectRetrograde Intrarenal Surgeryen_US
dc.subjectUreteral Access Sheathen_US
dc.subjectDual Lumen Ureteral Access Sheathen_US
dc.titleComparison of retrograde intrarenal stone surgery with and without a ureteral access sheath using kidney injury molecule-1 (KIM-1) levels: a prospective randomized studyen_US
dc.typeArticleen_US

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