Acrylamide reduces plasma antioxidant vitamin levels in rats due to increased oxidative damage

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dc.contributor.authorYener, Yesim
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.date.accessioned2024-02-23T14:30:09Z
dc.date.available2024-02-23T14:30:09Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjective Acrylamide is a potentially neurotoxic and carcinogenic chemical and naturally creates during the heating process of carbohydrate-rich foods, such as potato chips and breakfast cereals. Acrylamide might be ingested by people via consuming food that contains it. Therefore, we investigated the effect of acrylamide given orally to male and female rats on plasma retinoic acid and alpha-tocopherol and serum sialic acid and malondialdehyde levels. Method A total of 50 Wistar rats were used (25 female and 25 male, three-four weeks old). The rats of each sex were given 2 and 5mg/kg/day acrylamide via drinking water for 90 days. At the end of the treatment, the animals were euthanized by cervical dislocation. Blood specimens were collected through cardiac puncture, and serum and plasma samples were analysed using the high-performance liquid chromatography technique with a Ultraviolet detector. Results The analysis of the plasma and serum samples revealed that serum sialic acid and malondialdehyde levels in both sexes given 5mg/kg/day acrylamide were significantly increased, and the serum sialic acid levels were higher in female rats given 2mg/kg/day acrylamide. The plasma retinoic acid and alpha-tocopherol levels significantly decreased in both sexes given only the highest dose. Conclusion The results show that acrylamide causes an increase in oxidative stress and leads to a decrease in the levels of retinoic acid and alpha-tocopherol which play a role in the defense mechanism against this stress.en_US
dc.identifier.doi10.1590/1678-9865202033e180232
dc.identifier.issn1415-5273
dc.identifier.scopus2-s2.0-85084198096en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1590/1678-9865202033e180232
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15033
dc.identifier.volume33en_US
dc.identifier.wosWOS:000508622800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPontificia Universidade Catolica Campinasen_US
dc.relation.ispartofRevista De Nutricao-Brazilian Journal Of Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcrylamideen_US
dc.subjectMalondialdehydeen_US
dc.subjectRetinoic Aciden_US
dc.subjectSialic Aciden_US
dc.subjectAlpha-Tocopherolen_US
dc.titleAcrylamide reduces plasma antioxidant vitamin levels in rats due to increased oxidative damageen_US
dc.typeArticleen_US

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