Delirium in patients with acute ischemic stroke admitted to the non-intensive stroke unit: Incidence and association between clinical features and inflammatory markers

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dc.contributor.authorKozak, Hasan Huseyin
dc.contributor.authorUguz, Faruk
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorUca, Ali Ulvi
dc.contributor.authorTokgoz, Osman Serhat
dc.contributor.authorAkpinar, Zehra
dc.contributor.authorOzer, Nejla
dc.date.accessioned2024-02-23T14:13:35Z
dc.date.available2024-02-23T14:13:35Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground: Stroke patients with development of delirium have unfavorable outcomes, higher mortality, longer hospitalizations, and a greater degree of dependence after discharge. Studies suggest that delirium is associated with abnormal immunological responses and a resultant increase in inflammatory markers. Objective: Our aim was to determine whether there is an entity relationship between delirium, inflammation and acute ischemic stroke (AIS). Methods: Sixty AIS patients admitted to the hospital were consecutively recruited. Delirium was diagnosed with the clinical assessment according to the Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of Interleukin-1 beta (IL-1 beta), Interleukin 18 (IL-18), Tumor Necrosis Factor-alpha (TNF-alpha), Brain-Derived Neurotrophic Factor (BDNF), and Neuron Specific Enolase (NSE) at admission. Results: Eleven (18.3%) of 60 patients were diagnosed with delirium, and the majority (n = 8, 72.7%) was the hypoactive type. Delirious and non-delirious patients had similar demographic and clinical features. Delirious patients had significantly higher lengths of hospital stay, National Institutes of Health Stroke Scale (NIHSS) at admission and discharge compared to non-delirious patients. In addition, there was no significant statistical difference between delirious and non-delirious patients with AIS in respect of levels of TNF-alpha, IL-1 beta, IL-18, BDNF and NSE. This study suggests that delirium is not scarce in patients with AIS admitted to the non-intensive stroke unit, and that delirium developing after AIS seems not to be associated with serum TNF-alpha, IL-1 beta, IL-18, BDNF and NSE but is associated with length of hospital stay and stroke severity. (C) 2016 Published by Elsevier Sp. z o.o. on behalf of Polish Neurological Society.en_US
dc.description.sponsorshipNecmettin Erbakan Universityen_US
dc.description.sponsorshipThis research was supported by Research found of the Necmettin Erbakan University.en_US
dc.identifier.doi10.1016/j.pjnns.2016.10.004
dc.identifier.endpage44en_US
dc.identifier.issn0028-3843
dc.identifier.issue1en_US
dc.identifier.pmid27816188en_US
dc.identifier.scopus2-s2.0-85005870169en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.1016/j.pjnns.2016.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12490
dc.identifier.volume51en_US
dc.identifier.wosWOS:000394831400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofNeurologia I Neurochirurgia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDeliriumen_US
dc.subjectInflammationen_US
dc.subjectCytokineen_US
dc.subjectNon-Intensive Care Stroke Uniten_US
dc.subjectAcute Ischemic Strokeen_US
dc.titleDelirium in patients with acute ischemic stroke admitted to the non-intensive stroke unit: Incidence and association between clinical features and inflammatory markersen_US
dc.typeArticleen_US

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