Outcomes of Planned Marginal and Wide Resection of Sarcomas Associated with Major Vascular Structures in Extremities

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dc.contributor.authorKekec, Ahmet Fevzi
dc.contributor.authorGunaydin, Ilknur
dc.contributor.authorOzturk, Recep
dc.contributor.authorGungor, Bedii Safak
dc.date.accessioned2024-02-23T13:59:59Z
dc.date.available2024-02-23T13:59:59Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBone and soft tissue sarcomas of lower and upper extremities may sometimes be in close contact with neurovascular structures. In such cases, it is controversial that whether en bloc resection and vascular reconstruction to reach wider surgical margins or planned marginal resection with the help of adjuvant therapies should be preferred. This study aimed to determine surgical and oncological outcomes of planned marginal and wide resection of extremity sarcomas that are associated with major vascular structures in the extremities. The collected database of 54 patients treated by the same orthopedic and vascular surgeon for primary or locally recurrent soft and bone tissue sarcoma of extremities was retrospectively reviewed. Eligible subjects for this study were patients diagnosed with upper and lower extremity soft and bone tissue sarcomas that encased a maximum of 50% of the circumference of the major vascular structures, requiring limb-sparing resection. When microscopic positive (19 patients, 33.9%) and negative cases' (35 patients, 66.1%) surgical margins were compared, local recurrence, metastasis, amputation, and tumor type (soft/bone) parameters showed no statistically significant difference. When metastatic and non-metastatic patients were compared, it was shown that bone tumors metastasized more than soft tissue tumors (p = 0.001). However, there was no difference between metastasis and amputation, histopathology, grade, nerve involvement, surgical margins, or local recurrences. The mean survival was 1460.6 +/- 137.4 days, and the 6-year mortality was 87.5%. Anesthetic and surgical complication rates may be higher since en bloc resection surgeries of large tumors with vascular reconstructions take a very long time. Therefore, we suggest marginal resection with sub-adventitial dissection in those locations and wide resection at other areas according to the surgeon's experiences about safe margin with the contribution of radiotherapy.en_US
dc.identifier.doi10.1007/s13193-021-01476-5
dc.identifier.endpage402en_US
dc.identifier.issn0975-7651
dc.identifier.issn0976-6952
dc.identifier.issue2en_US
dc.identifier.pmid35782812en_US
dc.identifier.scopus2-s2.0-85119667295en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.1007/s13193-021-01476-5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11409
dc.identifier.volume13en_US
dc.identifier.wosWOS:000721404000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Surgical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExtremity Sarcomasen_US
dc.subjectLimb Salvageen_US
dc.subjectMusculoskeletal Tumoren_US
dc.subjectVascular Invasionen_US
dc.subjectVascular Reconstructionen_US
dc.titleOutcomes of Planned Marginal and Wide Resection of Sarcomas Associated with Major Vascular Structures in Extremitiesen_US
dc.typeArticleen_US

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