Effects of alpha-tocopherol on gingival expression of inducible nitric oxide synthase in the rats with experimental periodontitis and diabetes

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dc.contributor.authorHatipoglu, M.
dc.contributor.authorAlptekin, N. O.
dc.contributor.authorAvunduk, M. C.
dc.date.accessioned2024-02-23T14:37:45Z
dc.date.available2024-02-23T14:37:45Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBackground: The aim of this study was to investigate effects of -tocopherol and/or insulin on the number of gingival inducible nitric oxide synthase (iNOS) positive cells in rats with experimental periodontitis with or without streptozotocin (STZ)-induced diabetes. Materials and Methods: A total of 60 Sprague-Dawley rats were divided into three groups: Group I: The group without diabetes; Group II: The group with STZ-induced diabetes; Group III: The group with STZ-induced diabetes receiving insulin therapy. All animals received anesthesia, and 3/0 silk suture was inserted around the mandibular molar teeth. All groups were divided into subgroups receiving saline (Groups IA, IIA, IIIA) and -tocopherol injection (Groups IB, IIB, IIIB). After a period of 3 weeks, all rats were sacrificed, and the number of gingival iNOS positive cells was analyzed using image analysis software. Results: Applying -tocopherol suppressed the number of gingival iNOS positive cells in Groups IB, IIB, and IIIB compared to application of saline (Groups IA, IIA, and IIIA) (P 0.05). Numbers of gingival iNOS positive cells were found to be similar in the Groups I and III (P 0.05). Conclusions: Within limitations of the current study, this is the first study one may suggest that -tocopherol may reduce oxidative damage in the gingiva of the rats with periodontitis with or without STZ-induced diabetes and increase effects of insulin.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Selcuk University Konya, Turkey [09202002]en_US
dc.description.sponsorshipThis study was supported by Scientific Research Projects Coordination Unit of Selcuk University Konya, Turkey (Project Number: 09202002).en_US
dc.identifier.doi10.4103/1119-3077.183301
dc.identifier.endpage485en_US
dc.identifier.issn1119-3077
dc.identifier.issue4en_US
dc.identifier.pmid27251964en_US
dc.identifier.scopus2-s2.0-84973401191en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage480en_US
dc.identifier.urihttps://doi.org/10.4103/1119-3077.183301
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16226
dc.identifier.volume19en_US
dc.identifier.wosWOS:000378282700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectExperimental Periodontitisen_US
dc.subjectInducible Nitric Oxide Synthaseen_US
dc.subject-Tocopherolen_US
dc.titleEffects of alpha-tocopherol on gingival expression of inducible nitric oxide synthase in the rats with experimental periodontitis and diabetesen_US
dc.typeArticleen_US

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