Successful management of thrombotic thrombocytopenic purpura associated with pregnancy

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dc.contributor.authorBilgin, Aynur Ugur
dc.contributor.authorKaraselek, Mehmet Ali
dc.contributor.authorCamli, Kazim
dc.date.accessioned2024-02-23T14:16:28Z
dc.date.available2024-02-23T14:16:28Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractThrombotic thrombocytopenic purpura (TTP) is an uncommon, severe, potentially life-threatening disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, altered mental status, fever, and renal abnormalities. It can be seen at any age or sex but affects women of childbearing age more commonly. Pregnancy is known as one of the most common precipitating events for the onset of TTP and occurs mostly in the late third trimester or during the puerperium. Because of relatively low prevalence of pregnancy-related TTP, here we report the clinical characteristics and successful outcomes of 7 women with pregnancy-related TTP. Median age of patients was 25 (19-32). While 4 out of 7 women were primiparous, others were multiparous. Total plasma exchange (TPE) procedure was started within 24 h after admission to our hospital. All patients got into complete remission without any maternal mortality. Fetal mortality was found to be 28%. Pregnancy-related TTP is still associated with high maternal and fetal mortality rates. However, the prognosis of TTP has improved dramatically with early diagnosis and plasma-based therapies. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.transci.2014.02.023
dc.identifier.endpage437en_US
dc.identifier.issn1473-0502
dc.identifier.issue3en_US
dc.identifier.pmid24667160en_US
dc.identifier.scopus2-s2.0-84926096814en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage433en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2014.02.023
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12652
dc.identifier.volume50en_US
dc.identifier.wosWOS:000338603700020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion And Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTtpen_US
dc.subjectTherapeutic Apheresisen_US
dc.subjectPregnancyen_US
dc.titleSuccessful management of thrombotic thrombocytopenic purpura associated with pregnancyen_US
dc.typeArticleen_US

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