The effects of melatonin on the healing of burn wounds in pinealectomized rats

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dc.contributor.authorSari, E. Cigdem Karadag
dc.contributor.authorSavaci, Nedim
dc.date.accessioned2024-02-23T14:31:41Z
dc.date.available2024-02-23T14:31:41Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: The present study aims to investigate the favorable effects of melatonin on burn wound healing in rats. METHODS: In this study, forty Wistar-albino-type male rats were divided into four groups. Group 1 was the control group, Group 2 rats were treated using exogenous melatonin, Group 3 rats were pinealectomized, and Group 4 rats were pinealectomized then treated with exogenous melatonin. In all groups, a deep second-degree burn was created on the backs of the rats with a metal plate heated in boiling water. We monitored the progress of burn healing for seven days. At the end of them, we evaluated hydroxyproline levels, type III collagen, edema, inflammatory infiltration, congestion, vascular proliferation, fibrosis, the thickness of the zone of stasis and the epithelium to assess the progress of healing. RESULTS: The zone of stasis was less thick in Group 2 than the other groups (p=0.009). Type III collagen dyeing (p=0.031), fibrosis (p=0.011) and edema (p=0.031) were higher in Group 2 than the other groups. Congestion was higher in the control group than Group 4 (p=0.031). Other evaluated parameters showed no significant differences among the groups. CONCLUSION: In this study, it was noted that once total melatonin levels exceeded a certain threshold, a preventive effect was exerted on burn wound damage progression by reducing the zone of stasis. Melatonin may also prevent the development of hypertrophic scarring. Melatonin may be a potential therapeutic option that can supplement traditional treatment in burn wounds; however, further studies with higher doses of exogenous melatonin administered over longer periods are needed to further evaluate the effects noted in this study.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordination Uniten_US
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University Scientific Research Projects Coordination Unit.en_US
dc.identifier.doi10.14744/tjtes.2020.12247
dc.identifier.endpage401en_US
dc.identifier.issn1306-696X
dc.identifier.issue4en_US
dc.identifier.pmid34212993en_US
dc.identifier.scopus2-s2.0-85110299012en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2020.12247
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15308
dc.identifier.volume27en_US
dc.identifier.wosWOS:000669548700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBurnen_US
dc.subjectEndogenous Melatoninen_US
dc.subjectExogenous Melatoninen_US
dc.subjectPinealectomyen_US
dc.subjectWounden_US
dc.titleThe effects of melatonin on the healing of burn wounds in pinealectomized ratsen_US
dc.typeArticleen_US

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