Synthesis and evaluation of anticancer effect of a novel molecule based-on pillar[5]arene including multi quinoline units

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dc.contributor.authorGunes, Canan Eroglu
dc.contributor.authorKaraselek, Mehmet Ali
dc.contributor.authorKursunlu, Ahmed Nuri
dc.contributor.authorOzmen, Mustafa
dc.contributor.authorKurar, Ercan
dc.date.accessioned2024-02-23T13:43:28Z
dc.date.available2024-02-23T13:43:28Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractIn this study, pillar[5]arene containing ten terminal alkynyl-functional group was prepared and carried out an optimization procedure for target molecule with using 5-hydroxyquinoline molecule known with biological activity. The novel molecule was named as iso-QP[5] and characterized by FT-IR, melting point, NMR, elemental analysis, and mass spectroscopy. The aim was to evaluate the anticancer effects of iso-QP[5] on MCF7 human breast cancer cells. The IC50 dose of iso-QP[5] in MCF7 cells was found to be 25 mu M for 24 h using XTT assay. Expressions of eight genes for apoptosis were determined by qPCR. The results showed a significant increase in the expression of BAX, CASP3, CASP9, CYCS, and P53 genes after treatment with iso-QP[5] in MCF7 cells. However, iso-QP[5] treatment significantly decreased expression of BCL2 and CASP8 genes. It is concluded that novel molecule iso-QP[5] caused apoptosis by regulating genes that are important in apoptosis in human breast cancer cells.en_US
dc.description.sponsorshipScientific Research Projects Foundation of Necmettin Erbakan University (BAP) [1512180023]en_US
dc.description.sponsorshipThe authors express their appreciation to Prof ErsinGuler for helpful discussions. This research was supported by the Scientific Research Projects Foundation of Necmettin Erbakan University (BAP; #1512180023).en_US
dc.identifier.doi10.1007/s00044-020-02547-y
dc.identifier.endpage1083en_US
dc.identifier.issn1054-2523
dc.identifier.issn1554-8120
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85084242684en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1077en_US
dc.identifier.urihttps://doi.org/10.1007/s00044-020-02547-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10822
dc.identifier.volume29en_US
dc.identifier.wosWOS:000529323600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Birkhauseren_US
dc.relation.ispartofMedicinal Chemistry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCytotoxicityen_US
dc.subjectPillar[5]Areneen_US
dc.subjectQuinolineen_US
dc.titleSynthesis and evaluation of anticancer effect of a novel molecule based-on pillar[5]arene including multi quinoline unitsen_US
dc.typeArticleen_US

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