How does seminal plasma fatty-acid binding protein-9 level change in infertile males?

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dc.contributor.authorMenevse, E.
dc.contributor.authorSevinc, R.
dc.contributor.authorDursunoglu, D.
dc.contributor.authorAkdam, N.
dc.contributor.authorKorucu, E. N.
dc.date.accessioned2024-02-23T14:32:06Z
dc.date.available2024-02-23T14:32:06Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractIn recent years, free fatty acid binding proteins (FABPs) are implicated in spermatogenesis and sperm morphology. FABPs are members of the intracellular lipid-binding protein family; they exhibit tissue specific expression like the FABP9/PERF15 (Perforated15) male germ cell-specific fatty acid linkage-protein. The aim of the study was to assess the levels of seminal FABP-9 in normozoospermic and oligozoospermic men, and the possible relations between seminal FABP-9 levels and semen parameters. Research was carried out on 60 male volunteers who were admitted to Selcuk University Faculty of Medicine of Andrology Laboratory. Normozoospermic individuals (n = 30) were identified as Group 1, and Oligozoospermic individuals (n = 30) were identified as Group 2. The semen samples were collected in sterile plastic containers. Sperm parameters were assessed according to Kruger's criteria. Seminal plasma FABP-9 levels were analyzed by ELISA method. Outcomes were statistically evaluated at 0.05 significance level with SPSS (22.0). The Receiver Operating Characteristic (ROC) curve was used to evaluate the performance of FABP-9 levels as compared to that of the concentration and motility data of the sperm. FABP-9 levels were significantly higher in normozoospermic individuals (3.41 +/- 1.64 ng/mL) than in oligozoospermic individuals (1.99 +/- 0.78 ng/mL). There were significant correlations between FABP-9 levels and sperm concentration, total sperm count, motility, progressive motility, immobility, Total Progressive Motil Sperm Count (TPMSC), head anomaly, and teratozoospermia index. We suggest that FABP-9 level is an important biomarker, and low levels of semen FABP-9 may impact the fertility status based on the ROC findings.en_US
dc.description.sponsorshipSelcuk University [18202008]en_US
dc.description.sponsorshipThe research was funded by Selcuk University Scientific Research Project Coordinator (project no: 18202008).en_US
dc.identifier.doi10.1556/2060.2020.00035
dc.identifier.endpage430en_US
dc.identifier.issn2498-602X
dc.identifier.issue3en_US
dc.identifier.pmid33021953en_US
dc.identifier.scopus2-s2.0-85096224912en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage419en_US
dc.identifier.urihttps://doi.org/10.1556/2060.2020.00035
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15486
dc.identifier.volume107en_US
dc.identifier.wosWOS:000580590200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofPhysiology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfertile Maleen_US
dc.subjectSemenen_US
dc.subjectFatty Acid Binding Protein-9en_US
dc.subjectSpermyogramen_US
dc.subjectFertilityen_US
dc.titleHow does seminal plasma fatty-acid binding protein-9 level change in infertile males?en_US
dc.typeArticleen_US

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