Dry eye disease and ocular surface characteristics in patients with keratoconus

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dc.contributor.authorMirza, Enver
dc.contributor.authorOltulu, Refik
dc.contributor.authorOltulu, Pembe
dc.contributor.authorMirza, Gunsu D.
dc.contributor.authorOkka, Mehmet
dc.date.accessioned2024-02-23T14:37:55Z
dc.date.available2024-02-23T14:37:55Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractPURPOSE: The purpose of this study is to investigate the ocular surface alterations in patients with mild or severe keratoconus (KC). METHODS: A total of 80 participants were included in the study. The corneal topography was performed on each participant using Pentacam and the grouping was done accordingly. The patients with Kmax >= 52.0 D (severe KC) were considered Group 1 (n = 28), the patients with Kmax >= 47.2 and <52.0 D (mild KC) were considered Group 2 (n = 30). Healthy control participants with Kmax <47.2 D were considered Group 3 (n = 22). Tear breakup time (TBUT), Schirmer-I test, ocular surface disease index (OSDI) questionnaire, and conjunctival impression cytology (CIC) were evaluated among the groups. RESULTS: The mean values of TBUT and Schirmer-I test were significantly lower (P = 0.012, P = 0.012) and the mean scores of OSDI and CIC were significantly higher (P = 0.006, P < 0.001) in Group 1 and Group 2 than in Group 3. The mean values of TBUT and Schirmer-I test were lower and the mean scores of OSDI and CIC were higher in Group 1 than in Group 2 but the differences were insignificant (P > 0.05 for all). CONCLUSION: These results indicated that the tests associated with dry eye disease are correlated with KC. Tear film alterations and goblet cell loss are higher in severe KC.en_US
dc.identifier.doi10.4103/sjopt.sjopt_37_21
dc.identifier.endpage121en_US
dc.identifier.issn1319-4534
dc.identifier.issn2542-6680
dc.identifier.issue1en_US
dc.identifier.pmid35971496en_US
dc.identifier.scopus2-s2.0-85136994638en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.4103/sjopt.sjopt_37_21
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16288
dc.identifier.volume36en_US
dc.identifier.wosWOS:000868233400019en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofSaudi Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConjunctival Impression Cytologyen_US
dc.subjectDry Eye Diseaseen_US
dc.subjectGoblet Cell Densityen_US
dc.subjectKeratoconusen_US
dc.subjectTear Filmen_US
dc.titleDry eye disease and ocular surface characteristics in patients with keratoconusen_US
dc.typeArticleen_US

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