The role of melatonin in preventing radiation-induced intestinal injury

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dc.contributor.authorSezen, Orhan
dc.contributor.authorErdemci, Burak
dc.contributor.authorCalik, Muhammet
dc.contributor.authorKoc, Mehmet
dc.date.accessioned2024-02-23T14:49:26Z
dc.date.available2024-02-23T14:49:26Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractPurpose: Despite the therapeutic effects of radiotherapy on tumor cells, it has potential severe adverse effects on the sur- rounding normal tissues. Acute or chronic intestinal adverse effects that are likely to occur in patients undergoing radio- therapy for pelvic and abdominal cancers lead to increased morbidity, significant impairment of the quality of life, and economic losses. Various biological, chemical and pharma- cological agents are being tested to protect from and to treat radiation enteritis. This experimental study aimed to inves- tigate the protective effects of melatonin against radiation induced intestinal injury when administered before radiation exposure in rats. Methods: In the present study, villus height and the number of villi in the ileum and jejunum of rats receiving two dif- ferent doses of intraperitoneal melatonin (5 and 10 mg/kg) prior to a single fraction of radiation given at a dose of 8 Gy to the abdominal region, was evaluated by histopathological examination 3 and 7 days after radiation exposure. Results: At a dose of 5 mg/kg, melatonin was found to be effective in preventing radiation-induced injury to villus height in the jejunum and the number of villi in the ileum and jejunum, and at a dose of 10 mg/kg it was also effective in preventing radiation-induced injury to villus height in the ileum. Conclusions: Melatonin is effective for the prevention of radiation-induced intestinal injury. This outcome can be considered an evidence to test melatonin in clinical trials.en_US
dc.identifier.endpage633en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue2en_US
dc.identifier.pmid34077015en_US
dc.identifier.scopus2-s2.0-85105405967en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage626en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18189
dc.identifier.volume26en_US
dc.identifier.wosWOS:000646957600021en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal Of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestinal Injuryen_US
dc.subjectMelatoninen_US
dc.subjectRadiation Enteritisen_US
dc.subjectRadioprotectiveen_US
dc.subjectRadiotherapyen_US
dc.titleThe role of melatonin in preventing radiation-induced intestinal injuryen_US
dc.typeArticleen_US

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