Ganglion cell complex thickness changes in patients with different states of bipolar disorder

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dc.contributor.authorCokunlu, Yusuf
dc.contributor.authorMirza, Enver
dc.contributor.authorCaliskan, Ali Metehan
dc.contributor.authorInanli, Ikbal
dc.contributor.authorCicek, Ismet Esra
dc.contributor.authorOzcimen, Muammer
dc.contributor.authorEren, Ibrahim
dc.date.accessioned2024-02-23T14:16:44Z
dc.date.available2024-02-23T14:16:44Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjectives Neuroimaging studies in patients with bipolar disorder have suggested that a neuropathological process may be effective in this disease. Neurodegenerative changes in the retina can be followed by optical coherence tomography, a non-invasive imaging method that allows in vivo visualization of the retinal layers. The aim of this study was to investigate the possible differences in optical coherence tomography parameters during euthymic, manic, and depressive episodes in patients diagnosed with bipolar disorder. Methods A total of 150 patients with bipolar disorder were included in the study, divided into three groups (50 patients in a euthymic state, 50 patients in a manic state, and 50 patients in a depressive state) and compared with 50 healthy controls. Ganglion cell complex thickness was measured with automated macular segmentation software of spectral-domain optical coherence tomography. Results Ganglion cell complex thicknesses were thicker in all quadrants in patient groups than the control group but the differences were significant in perifoveal superior and perifoveal inferior quadrants (p < 0.001, p < 0.001). There were no differences in ganglion cell complex thickness among the patient groups (p > 0.05). Conclusion The evaluation of ganglion cell complex thickness by spectral-domain optical coherence tomography may give a clue for monitoring neurodegenerative changes in patients with bipolar disorder.en_US
dc.identifier.doi10.1038/s41433-021-01580-4
dc.identifier.endpage1041en_US
dc.identifier.issn0950-222X
dc.identifier.issn1476-5454
dc.identifier.issue5en_US
dc.identifier.pmid33976400en_US
dc.identifier.scopus2-s2.0-85105561777en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1034en_US
dc.identifier.urihttps://doi.org/10.1038/s41433-021-01580-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12758
dc.identifier.volume36en_US
dc.identifier.wosWOS:000649228400003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofEyeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleGanglion cell complex thickness changes in patients with different states of bipolar disorderen_US
dc.typeArticleen_US

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