Cardiovascular Disease Risk in Children and Adolescents with Attention Deficit/Hyperactivity Disorder

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dc.contributor.authorUzun, Necati
dc.contributor.authorAk, Mehmet Akif
dc.contributor.authorAlp, Hayrullah
dc.date.accessioned2024-02-23T14:44:58Z
dc.date.available2024-02-23T14:44:58Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjective: The aim of this case-controlled study is to evaluate chronic inflammation, subclinical atherosclerosis and cardiovascular disease risk in children and adolescents with ADHD.Methods: A total of 51 medication-free children and adolescents with ADHD and 51 healthy controls were included in this study. K-SADS-PL was used to determine the diagnosis of ADHD and other psychiatric disorders. Conners' Parent Rating Scale-Revised Short Form and the Conners' Teacher Rating Scale-Revised Short Form severity of ADHD was used to evaluate severity of ADHD. In order to evaluate subclinical atherosclerosis, common carotid intima media thickness (IMT), epicardial adipose tissue thickness (EAT), and periaortic adipose tissue thickness (PAT) were assessed as well as clinical parameters.Results: The IMT (0.037 +/- 0.005 cm vs. 0.026 +/- 0.003 cm), EAT (0.472 +/- 0.076 cm vs. 0.355 +/- 0.051 cm), and PAT (0.135 +/- 0.016 cm vs. 0.118 +/- 0.009 cm) measurements were significantly higher in the ADHD group than in the control group. Additionally, partial correlation analyses revealed that a positive correlation was observed between IMT and EAT, and PAT measurements separately. Multivariate linear regression analysis revealed that, body mass index (BMI) positively predicted IMT. Also, age and BMI positively predicted the EAT levels of the subjects with ADHD.Conclusion: Our results suggest that children and adolescents with ADHD have a risk for cardiovascular disease. For this reason, subclinical atherosclerosis should be taken into consideration in the follow-up and treatment of ADHD for cardiovascular disease risk.en_US
dc.identifier.doi10.9758/cpn.2023.21.1.77
dc.identifier.endpage87en_US
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.issue1en_US
dc.identifier.pmid36700314en_US
dc.identifier.scopus2-s2.0-85158064907en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.9758/cpn.2023.21.1.77
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17171
dc.identifier.volume21en_US
dc.identifier.wosWOS:000926578400003en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Coll Neuropsychopharmacologyen_US
dc.relation.ispartofClinical Psychopharmacology And Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAttention-Deficiten_US
dc.subjectHyperactivity Disorderen_US
dc.subjectIntima-Media Thicknessen_US
dc.subjectEpicardial Adipose Tissue Thicknessen_US
dc.subjectPeriaortic Adipose Tissue Thicknessen_US
dc.subjectChronic Inflammationen_US
dc.subjectCardiovascular Diseaseen_US
dc.titleCardiovascular Disease Risk in Children and Adolescents with Attention Deficit/Hyperactivity Disorderen_US
dc.typeArticleen_US

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