The effect of rebreathing and hyperventilation on retinal and choroidal vessels measured by spectral domain optical coherence tomography

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dc.contributor.authorOzcimen, Muammer
dc.contributor.authorSakarya, Yasar
dc.contributor.authorGoktas, Sertan
dc.contributor.authorSakarya, Rabia
dc.contributor.authorAlpfidan, Ismail
dc.contributor.authorYener, Halil I.
dc.contributor.authorDemir, Lutfi S.
dc.date.accessioned2024-02-23T14:34:39Z
dc.date.available2024-02-23T14:34:39Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractObjective: The purpose of this study was to examine the vasoreactivity in retina and choroid of the healthy eyes in response to experimentally altered partial arterial pressure of carbon dioxide (PaCO2) using a non-invasive technique, spectral domain optical coherence tomography (SD-OCT). Materials and methods: The study included non-smoking participants between 18 and 35 years of age, having visual acuity of 20/20 and with no systemic and ocular diseases. At baseline, the participants breathed room air (normocapnia). Hypocapnia was created with the help of hyperventilation; for this, the participants were instructed to draw deep and quick breaths, resulting one breathing cycle per 2 s. To create hypercapnia subjects rebreathed from a 5 l bag at least 3 min. Choroidal thickness and retinal artery diameter were measured at baseline, and hyperventilation and rebreathing conditions by SD-OCT. Results: Twenty eyes of 20 healthy subjects were included in this study. Their mean age was 24.90 +/- 5.32 years. Hyperventilation caused a significant reduction in choroidal thickness, compared with baseline, at all points; whereas rebreathing caused no significant change at all points. The mean diameters of the arteries were 151.80 +/- 7.88 mm, with a significant decline to 148.90 +/- 7.25 mm at hyperventilation condition and a significant increase to 153.50 +/- 7.88 mm at rebreathing condition (p = 0.018, p = 0.043, respectively). Conclusion: This study demonstrated that, SD-OCT was a useful tool in measuring the ocular vascular response under hypercapnia and hypocapnia conditions. These findings may be helpful for further understanding the physiological nature of ocular blood flow and this preliminary study provides a basis for future studies.en_US
dc.identifier.doi10.3109/15569527.2014.990154
dc.identifier.endpage317en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue4en_US
dc.identifier.pmid25597376en_US
dc.identifier.scopus2-s2.0-84946089721en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://doi.org/10.3109/15569527.2014.990154
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15689
dc.identifier.volume34en_US
dc.identifier.wosWOS:000371395000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous And Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon Dioxideen_US
dc.subjectChoroidal Blood Flowen_US
dc.subjectOcular Blood Flowen_US
dc.subjectRetinal Arteryen_US
dc.titleThe effect of rebreathing and hyperventilation on retinal and choroidal vessels measured by spectral domain optical coherence tomographyen_US
dc.typeArticleen_US

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