Stem cell and extracellular matrix-related molecules increase following melatonin treatment in the skin of postmenopausal rats

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dc.contributor.authorUslu, Serap
dc.contributor.authorOktem, Gulperi
dc.contributor.authorUysal, Aysegul
dc.contributor.authorSoner, Burak Cem
dc.contributor.authorArbak, Serap
dc.contributor.authorInce, Umit
dc.date.accessioned2024-02-23T11:26:17Z
dc.date.available2024-02-23T11:26:17Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractThe menopause has a negative effect in the skin. Melatonin affects skin functions and structures through actions mediated by cell-surface and putative-nuclear receptors expressed in skin cell. We have therefore determined the effects of melatonin treatment on stem cell in the epidermis and extracellular matrix related molecules in the dermis the skin of postmenopausal rats. A total of 45 female rats were divided into 5 groups: control group, group A [ ovariectomy (OVX)], group B (OVX +10 mg/kg/day melatonin), group C (OVX +30 mg/kg/day melatonin), group S (sham operated +10 mg/kg/day melatonin). Ventral skin samples were excised at 12th week after ovariectomy. Hematoxylin-eosin, periodic acid- methylamine silver, elastic van Gieson staining techniques were used to measure histomorphometrically the thickness of elastic fibers and basement membrane, depths of the epidermis, dermis, and subcutaneous fat layer. Immunohistochemical staining methods were used for fibroblast growth factor beta (FGF beta), collagen type I, fibronectin, beta-catenin, c-kit, c-Myc evaluation. Epidermal thickness, subcutaneous fat layer, and elastic fibers were significantly decreased in group C, and there was a significant increase after melatonin treatment. Although there was no difference in dermal thickness of group C, melatonin also significantly increased the dermal thickness. High FGF beta, type I collagen, fibronectin, beta-catenin, c-Myc immunoreactivity developed following melatonin in all groups. Thus melatonin treatment of postmenopausal rats was mostly due to the decrease of stem cell and extracellular matrix-related molecules in the skin.en_US
dc.identifier.doi10.1002/cbin.10286
dc.identifier.endpage932en_US
dc.identifier.issn1065-6995
dc.identifier.issn1095-8355
dc.identifier.issue8en_US
dc.identifier.pmid24740758en_US
dc.identifier.scopus2-s2.0-84904006160en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage924en_US
dc.identifier.urihttps://doi.org/10.1002/cbin.10286
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10541
dc.identifier.volume38en_US
dc.identifier.wosWOS:000339101900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExtracellular Matrixen_US
dc.subjectMelatoninen_US
dc.subjectMenopauseen_US
dc.subjectSkinen_US
dc.subjectStem Cellen_US
dc.titleStem cell and extracellular matrix-related molecules increase following melatonin treatment in the skin of postmenopausal ratsen_US
dc.typeArticleen_US

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