Effects of albumin and synthetic polypeptide-coated oxygenators on IL-1, IL-2, IL-6, and IL-10 in open heart surgery

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dc.contributor.authorSimsek, Erdal
dc.contributor.authorKarapinar, Kasim
dc.contributor.authorBugra, Onursal
dc.contributor.authorUlus, Ahmet Tulga
dc.contributor.authorSarigul, Ali
dc.date.accessioned2024-02-23T14:02:09Z
dc.date.available2024-02-23T14:02:09Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackground: In this study, we have tried to demonstrate the effects of coating style used in oxygenators on various hematologic and clinical parameters. Materials and methods: Twenty-seven patients were included in the study, who had undergone operations because of elective coronary artery disease. Albumin-coated oxygenator was used in Group I. In Group II, a synthetic polypeptide-coated oxygenator was used. C1-inhib (complement), C3c, C4, interleukins (IL-1 beta, IL2, IL-6, IL-10), and tumor necrosis factor alpha (THE-a) levels were examined at four different time intervals. Hemoglobin, hematocrit, leukocyte and platelet counts, drainage, and transfused blood volumes were analyzed. Results: Albumin levels were significantly lower in Group I than those in Group II 5 minutes after the removal of the cross-clamp. Twenty-four hours after the surgery, Group I patients also had a significantly higher white blood cell count compared to Group II patients. THE-a levels in Group I were always expressed in considerably higher amounts than those in Group II. IL-6 levels were significantly higher in Group I, but IL-10 levels were observed to be higher in Group II (p < 0.05). Conclusion: Synthetic polypeptide-coated advanced technology, which employed oxygenators, had an important attenuator effect on acute phase reactants and also on the inflammatory response. Copyright (C) 2013, Asian Surgical Association. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.identifier.doi10.1016/j.asjsur.2013.09.004
dc.identifier.endpage99en_US
dc.identifier.issn1015-9584
dc.identifier.issn0219-3108
dc.identifier.issue2en_US
dc.identifier.pmid24210839en_US
dc.identifier.scopus2-s2.0-84897581555en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1016/j.asjsur.2013.09.004
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11613
dc.identifier.volume37en_US
dc.identifier.wosWOS:000335285600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Singapore Pte Ltden_US
dc.relation.ispartofAsian Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComplementen_US
dc.subjectInterleukinen_US
dc.subjectOxygenatoren_US
dc.subjectSystemic Inflammatory Response Syndromeen_US
dc.titleEffects of albumin and synthetic polypeptide-coated oxygenators on IL-1, IL-2, IL-6, and IL-10 in open heart surgeryen_US
dc.typeArticleen_US

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