Responses of acrylamide-treated rat bladders

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dc.contributor.authorNurullahoglu-Atalik, E.
dc.contributor.authorOkudan, N.
dc.contributor.authorBelviranli, M.
dc.contributor.authorEsen, H.
dc.contributor.authorYener, Y.
dc.contributor.authorCelik, I
dc.date.accessioned2024-02-23T14:37:57Z
dc.date.available2024-02-23T14:37:57Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractObjective: Acrylamide (ACR) is a chemical used in many industries around the world and more recently was found to be formed naturally in foods cooked at high temperatures. ACR was shown to be a neurotoxicant, reproductive toxicant, and carcinogen in animal species. The aim of the present study is to evaluate the influence of ACR treatment on urinary bladder responses to carbachol (10(-9)-3x10(-4) M) and potassium chloride (KCl; 5-100 mM), each of them causes receptor-dependent and receptor-independent contractions, respectively. We also examined the role of gender in these responses. Material and methods: Rats of both genders were divided into three groups as follows: (1) Control animals (2) ACR-I; ACR-treated (2 mg/kg-d for 90 days) (3) ACR-II; ACR-treated (5 mg/kg-d for 90 days). Results: In rats treated with ACR, the EC50 values of carbachol and KCl, but not the maximal response, to both agents were significantly higher than in control group. Histopathological parameters such as edema, congestion, inflammatory cells, microvascular proliferation, fibrosis, eosinophils, mast cells and epithelial damage were all higher in the ACR-treated group than in the controls. Conclusions: These results demonstrate for the first time that ACR-treatment can induce urinary bladder injury (Tab. 4, Fig. 4, Ref. 30). Full Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2013_002
dc.identifier.endpage11en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue1en_US
dc.identifier.pmid23253020en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2013_002
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16306
dc.identifier.volume114en_US
dc.identifier.wosWOS:000313776200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcrylamideen_US
dc.subjectBladderen_US
dc.subjectCarbacholen_US
dc.subjectContractionsen_US
dc.subjectGenderen_US
dc.subjectKclen_US
dc.titleResponses of acrylamide-treated rat bladdersen_US
dc.typeArticleen_US

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