Blood urea nitrogen to albumin ratio is a predictor of in-hospital mortality in older emergency department patients

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dc.contributor.authorDundar, Zerrin Defne
dc.contributor.authorKucukceran, Kadir
dc.contributor.authorAyranci, Mustafa Kursat
dc.date.accessioned2024-02-23T14:02:03Z
dc.date.available2024-02-23T14:02:03Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIntroduction: In this study, we aimed to evaluate the first measured blood urea nitrogen (BUN)/albumin ratio in the emergency department (ED) as a predictor of in-hospital mortality in older ED patients. Methods: This retrospective observational study was conducted at a university hospital ED. Consecutive patients aged 65 and over who visited the ED in a three-month period were included in the study. The BUN, albumin, creatinine, and estimated glomerular filtration rate (eGFR) of patients were recorded. The primary end point of the study was in-hospital mortality. Results: A total of 1253 patients were included in the statistical analyses of the study. Non-survivors had increased BUN levels (32.9 (23.3-55.4) vs. 20.2 (15.4-28.3) mg/dL, p < 0.001), decreased albumin levels (3.27 (2.74-3.75) vs. 3.96 (3.52-4.25) g/dL, p < 0.001), and increased BUN/albumin ratios (10.19 (6.56-18.94) vs. 5.21 (3.88-7.72) mg/g, p < 0.001) compared to survivors. An increased BUN/albumin ratio was a powerful predictor of in-hospital mortality with an area under the curve of 0.793 (95% CI: 0.753-0.833). Malignancy (OR: 2.39; 95% CI: 1.59-3.74, p < 0.001), albumin level < 3.5 g/dL (OR: 2.75; 95% CI: 1.74-4.36, p < 0.001), and BUN/albumin ratio > 6.25 (OR: 2.82; 95% CI: 1.22-6.50, p < 0.015) were found to be independent predictors of in-hospital mortality in older ED patients. Conclusion: According to our findings, older patients with a BUN level > 23 mg/dL, an albumin level < 3.5 g/dL, and a BUN/albumin ratio > 6.25 mg/g in the ED have a higher risk of in-hospital mortality. Additionally, the BUN/albumin ratio is a more powerful independent predictor of in-hospital mortality than the BUN level, albumin level, creatinine level, and eGFR in older ED patients. (c) 2020 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.ajem.2020.10.008
dc.identifier.endpage354en_US
dc.identifier.issn0735-6757
dc.identifier.issn1532-8171
dc.identifier.pmid33069540en_US
dc.identifier.scopus2-s2.0-85092690137en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2020.10.008
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11550
dc.identifier.volume46en_US
dc.identifier.wosWOS:000681307200064en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEmergencyen_US
dc.subjectOlderen_US
dc.subjectBlood Urea Nitrogenen_US
dc.subjectAlbuminen_US
dc.subjectMortalityen_US
dc.titleBlood urea nitrogen to albumin ratio is a predictor of in-hospital mortality in older emergency department patientsen_US
dc.typeArticleen_US

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