The role of torque teno virus (TTV) viremia in sarcoidosis etiology

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dc.contributor.authorTeke, Turgut
dc.contributor.authorFeyzioglu, Bahadir
dc.contributor.authorTosun, Mustafa
dc.contributor.authorDogan, Metin
dc.contributor.authorYesildag, Kerim
dc.contributor.authorOzdemir, Mehmet
dc.date.accessioned2024-02-23T14:49:15Z
dc.date.available2024-02-23T14:49:15Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractObjective: To investigate a possible role of torque teno virus (TTV) in the etiology of sarcoidosis Design: Controlled prospective study Setting: Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey Subjects: This cross-sectional, clinical study included 37 sarcoidosis patients and 9 healthy control patients. Intervention: TTV DNA quantification was performed by real-time PCR by the hybridization probe system, and viral load was interpreted by means of the crossing point (CP) value in sera of subjects. Main outcome measures: The prevalence and viral load of TTV Results: TTV DNA was detected in the majority of both patients and healthy controls. The prevalence was 59.5% in patients and 55.6% in controls. This difference was not statistically significant. However, CP values were statistically different in the patient group from the control group (p < 0.001); namely, the viral load of TTV was higher in the patient group than in the healthy control group. Conclusions: Overall, these findings demonstrate for the first time that TTV plays a role in the etiology of sarcoidosis. It is likely that the role of TTV in the pathogenesis of sarcoidosis is an aberrant immune response, driven by viral antigens.en_US
dc.identifier.endpage162en_US
dc.identifier.issn0023-5776
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85075281069en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18076
dc.identifier.volume51en_US
dc.identifier.wosWOS:000488219700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKuwait Medical Assocen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEtiologyen_US
dc.subjectInfectionen_US
dc.subjectSarcoidosisen_US
dc.subjectTorque Teno Virusen_US
dc.titleThe role of torque teno virus (TTV) viremia in sarcoidosis etiologyen_US
dc.typeArticleen_US

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