Investigation of Respiratory Tract Pathogen Human Parechoviruses in Konya, Turkey

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dc.contributor.authorTokak, Semih
dc.contributor.authorOzdemir, Mehmet
dc.contributor.authorTasbent, Fatma Esenkaya
dc.date.accessioned2024-02-23T14:16:58Z
dc.date.available2024-02-23T14:16:58Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjective This study aims to better understand the epidemiological characteristics of parechoviruses and to determine the genotype distribution in Konya, Turkey. Methods In this study, nasal and throat swab samples taken from 1,110 children who were diagnosed with respiratory tract infection (bronchitis, pneumonia, asthmatic bronchitis, and other respiratory diseases) and applied to various pediatric polyclinics of Meram Medical Faculty Hospital, Necmettin Erbakan University between September 2017 and March 2019 were evaluated. Human parechovirus (HPeV) RNA was investigated by multiplex polymerase chain reaction (PCR) in respiratory tract samples. Specific genotypes of the positive samples were identified by real-time PCR amplification of the VP1 region followed by sequence analysis. Results Of the total of 1,110 samples, 4 were positive for HPeV. Of these, HPeV1 was the most predominant genotype ( n = 3), followed by HPeV4 ( n = 1). HPeV infections were detected throughout the year in Konya, Turkey. Conclusion Although the number of positive samples for HPeV is low, these findings provide information about the genetic diversity and epidemiological of HPeV genotypes circulating in pediatric patients in Turkey. This is the first study to detect prevalence and genotyping of HPeV in respiratory tract infections in Turkey. HPeVs should be considered as causative agents especially in infants with sepsis, meningitis, or encephalitis, and routine testing panels for HPeV detection should be available in hospital laboratories. Further studies using molecular epidemiological methods will be beneficial for identifying genotypes of all HPeVs involved in the etiology and for better monitoring of these infections.en_US
dc.identifier.doi10.1055/s-0039-3401892
dc.identifier.endpage90en_US
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85081146428en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://doi.org/10.1055/s-0039-3401892
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12859
dc.identifier.volume15en_US
dc.identifier.wosWOS:000518695400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal Of Pediatric Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenotypingen_US
dc.subjectHpeven_US
dc.subjectRespiratory Tract Infectionen_US
dc.subjectRt-Pcren_US
dc.titleInvestigation of Respiratory Tract Pathogen Human Parechoviruses in Konya, Turkeyen_US
dc.typeArticleen_US

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